HIV Care Cascade and Linkage to Antiretroviral Therapy Among Hospitalized Adults in Lusaka, Zambia
- Conditions
- Hiv
- Registration Number
- NCT03158844
- Lead Sponsor
- University of Alabama at Birmingham
- Brief Summary
The population of inpatients is large in Zambia; however, because of poor linkages between hospitals and community HIV care, there are few data to analyze their engagement in HIV care before and after hospitalization. The goal of the study is to learn more about Zambian adults who are HIV-infected and get hospitalized. The purpose of this study is to gather formative, preliminary data, to be used in future grant applications to improve linkage and engagement in HIV care in Zambia.
- Detailed Description
The main objective of this study is to generate preliminary data on the outcomes of Zambian HIV-infected individuals after discharge from University Teaching Hospital (UTH) Internal Medicine wards which can inform development of a linkage intervention. Our central hypothesis is that in Sub-Saharan African settings like Zambia hospitalizations among HIV-infected individuals are driven by suboptimal linkage and initiation of ART following HIV diagnosis. Specific Aims: (a) Characterize the distribution of hospitalized 300 HIV-infected adults across the HIV care continuum. (b) Identify structural, psychosocial, clinic, and medical factors that predict suboptimal linkage to care and ART initiation after 90 days of hospital discharge among HIV-infected Zambians.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 250
- 18 years or older
- HIV-infected as documented in the UTH file
- Admitted to Internal Medicine Ward at UTH
- Unable to provide informed consent
- Not planning to remain in Lusaka province for 3 months after discharge
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Undetectable HIV viral load at 90 days post-discharge 90 days after hospital discharge Numerator is number with HIV RNA \<1000 c/mL tested at 90 days after hospital discharge; denominator is the # enrolled
- Secondary Outcome Measures
Name Time Method Proportion of HIV-infected inpatients who are on ART upon admission Baseline Numerator is number who report taking ART up to the time of admission; denominator is the # enrolled
Mortality rate 90 days after hospital discharge Mortality from time of enrollment to 90 days after discharge
ART initiation Baseline and 90 days after hospital discharge Proportion not on ART upon admission to hospital who are on ART at 90 days after hospital discharge
Trial Locations
- Locations (1)
University Teaching Hospital
🇿🇲Lusaka, Zambia
University Teaching Hospital🇿🇲Lusaka, Zambia