Inpatient Package to Reduce HIV and AIDS-related Death in Zambia
Not Applicable
Completed
- Conditions
- TuberculosisHIV TestingHIV/AIDSTransitions of CareCryptococcosisHospitalization
- Registration Number
- NCT04033718
- Lead Sponsor
- University of Alabama at Birmingham
- Brief Summary
Early post-discharge mortality is high among HIV-infected Zambians admitted to the hospital. Likely this is in part due to missed opportunities to identify lethal coinfections and optimize HIV care during admission (and before discharge). In this study the investigators will develop and pilot a new approach to inpatient HIV care that follows international guidelines for management of advanced HIV disease.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 72
Inclusion Criteria
- 18+ years old
- HIV-positive (by self-report or DCT result in UTH file)
- Resident of Lusaka
- Admitted to the hospital
Exclusion Criteria
- Too sick to provide informed consent (based on clinician opinion)
- Likely to be discharged in the next 48 hours (based on clinician opinion)
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Primary Outcome Measures
Name Time Method Coinfection diagnosis Through hospital discharge, an average of 2 weeks Positive test for tuberculosis or cryptococcus on admission
- Secondary Outcome Measures
Name Time Method
Related Research Topics
Explore scientific publications, clinical data analysis, treatment approaches, and expert-compiled information related to the mechanisms and outcomes of this trial. Click any topic for comprehensive research insights.
What molecular mechanisms underlie the effectiveness of inpatient lab bundling in managing advanced HIV disease in Zambia?
How does inpatient navigation improve adherence to antiretroviral therapy compared to standard care in HIV patients with tuberculosis co-infection?
Which biomarkers are most predictive of response to cryptococcosis screening and treatment in the context of NCT04033718?
What adverse events are associated with bundled diagnostic testing for HIV-related co-infections in sub-Saharan African hospitals?
How do combination approaches of lab bundling and navigation compare to existing interventions in reducing post-discharge mortality for HIV/AIDS patients in Zambia?
Trial Locations
- Locations (1)
University Teaching Hospital
🇿🇲Lusaka, Zambia
University Teaching Hospital🇿🇲Lusaka, Zambia