Comparison of daily oral iron treatment with alternate day treatment for correction of iron deficiency anemia
Phase 3
Completed
- Conditions
- Health Condition 1: D508- Other iron deficiency anemias
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 68
Inclusion Criteria
Newly diagnosed iron deficiency anaemia patients, with haemoglobin concentration between 6-10 g/dl, with peripheral blood smear suggestive of iron deficiency anemia and with serum ferritin level <30 mcg/l
Exclusion Criteria
1. Pregnant and lactating women
2. Already diagnosed to have iron deficiency anemia and on treatment
3. Known coronary artery disease/chronic heart failure
4. History of overt gastrointestinal bleeding (haematemesis/ melena)
5. Chronic kidney disease (serum creatinine >2 mg/dl)
6. Known malabsorption
7. Heavy alcohol abuse (alcohol intake >once/week)
8. Dimorphic anaemias
9. History of peptic ulcer disease on long term acid suppressive therapy
10. Known anaemia of chronic disease (SLE/rheumatoid arthritis/HIV infection/ Tuberculosis)
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method To assess the quantum of haemoglobin increment in once daily and alternate day oral iron replacement arms on Day-28Timepoint: To assess the quantum of haemoglobin increament in once daily and alternate day oral iron replacement on Days-14 and 28
- Secondary Outcome Measures
Name Time Method 1.To study the effect of oral iron replacement on serum hepcidin levels in the two arms at baseline and on Day-14 <br/ ><br>2.To determine frequency of adverse events and compliance with therapy in the two arms <br/ ><br>3.To assess the increment in haemoglobin concentration in the two arms on Day-56Timepoint: Day-0 (Start of intervention), Day-7,Day-14,Day-28,Day-42 and Day-56