Correlation of lung and gut microbiome of critically ill patients: A Cross-Sectional Study
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 25
- 试验地点
- 1
- 主要终点
- To correlate the microbiome of the lung & gut in critically ill intubated patients on day 5 of ICU admission using metagenomic analysis.
研究概览
简要总结
In critically ill patients requiring mechanical ventilation due to any cause, micro-aspiration is believed to be responsible for respiratory infection, thus the development of “ventilator bundles†such as oral care, head of bed-elevation, airway suction and aspiration prophylaxis. Regardless of these interventions, pneumonia continues to be a complication in Intensive Care Unit (ICU) patients with high mortality. Our study data will help understand if lung is enriched with the gut microbiome in intubated patients admitted in ICU. Understanding these correlations between the lung and gut microbiome in critically ill patients may have potential role in the development of new treatment strategies.
研究设计
- 研究类型
- Observational
入排标准
- 年龄范围
- 18.00 Year(s) 至 75.00 Year(s)（—）
- 性别
- All
入选标准
- •Admitted in Intensive care unit intubated and on mechanical ventilation will be included in this study.
排除标准
- •i)Patients who desaturate during routine endotracheal suctioning ii)Fraction of inspired oxygen (FiO2) >0.80 iii)Positive end expiratory pressure (PEEP) > 10 cm H2O iv)Prone position v)Thrombocytopenia (platelet count <50,000) or coagulopathy (INR >1.5).
结局指标
主要结局
To correlate the microbiome of the lung & gut in critically ill intubated patients on day 5 of ICU admission using metagenomic analysis.
时间窗: Day 5 of ICU stay
次要结局
- Analyse the predominant microbiome composition in the lung & the gut.(Day 5 of ICU stay)