Study of microbes present in the lung and abdomen in sick patients admitted in Intensive Care unit

Recruiting

• Conditions: Acute and chronic respiratory failure,

• Registration Number: CTRI/2023/12/060665
• Lead Sponsor: All India Institute of Medical Sciences

Brief Summary

In critically ill patients requiring mechanical ventilation due to any cause, micro-aspiration is believed to be responsible for respiratory infection, thus the development of “ventilator bundles†such as oral care, head of bed-elevation, airway suction and aspiration prophylaxis. Regardless of these interventions, pneumonia continues to be a complication in Intensive Care Unit (ICU) patients with high mortality. Our study data will help understand if lung is enriched with the gut microbiome in intubated patients admitted in ICU. Understanding these correlations between the lung and gut microbiome in critically ill patients may have potential role in the development of new treatment strategies.

Detailed Description

Not available

Study Timeline

• Study Start: 2024-01-01
• Last Update Posted: 2024-07-29

Recruitment & Eligibility

• Status: Open to Recruitment
• Sex: All
• Target Recruitment: 25

Inclusion Criteria

Admitted in Intensive care unit intubated and on mechanical ventilation will be included in this study.

Exclusion Criteria

i)Patients who desaturate during routine endotracheal suctioning ii)Fraction of inspired oxygen (FiO2) >0.80 iii)Positive end expiratory pressure (PEEP) > 10 cm H2O iv)Prone position v)Thrombocytopenia (platelet count <50,000) or coagulopathy (INR >1.5).

Study & Design

• Study Type: Observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
To correlate the microbiome of the lung & gut in critically ill intubated patients on day 5 of ICU admission using metagenomic analysis.	Day 5 of ICU stay

Secondary Outcome Measures

Name	Time	Method
Analyse the predominant microbiome composition in the lung & the gut.	Day 5 of ICU stay

Trial Locations

Locations (1)

All India Institute of Medical Sciences New Delhi; 🇮🇳 South, DELHI, India

All India Institute of Medical Sciences New Delhi

🇮🇳South, DELHI, India

Dr Choro Athiphro Kayina

Principal investigator

9654116228

kayinaathiphro@gmail.com