Alterations of the Microbiome During Critical Illness With Short and Long Term Clinical Outcomes
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Critical Illness
- Sponsor
- University of Chicago
- Enrollment
- 500
- Locations
- 1
- Primary Endpoint
- Long Term Mortality
- Status
- Active, not recruiting
- Last Updated
- 4 months ago
Overview
Brief Summary
This study is designed to study the variations in the microbiome among critically ill patients and the effect of admission to the medical intensive care unit (MICU) at the University of Chicago. Additionally, investigators will examine the downstream clinical effects of dysbiosis in ICU patients and how patients maybe effected long term.
Detailed Description
During this study investigators will longitudinally collect discarded stool biosamples throughout the MICU admission when available. Stool Bio specimens will be recorded/coded and processed by the investigators. Stool Bio specimens will be analyzed for 16sRNA and metabolomics. Surveys will be conducted at study entry, in addition to 6 months and 12 months following discharge. By longitudinally sampling discarded biospecimens from subjects throughout their MICU admission in additionally to describing long term following up. We will be able to correlate changes in the microbiome with clinical data, and follow up surveys to identify factors that may impact the composition of the microbiome and their impact on clinical outcomes.
Investigators
Eligibility Criteria
Inclusion Criteria
- •adult patients admitted to the intensive care unit
Exclusion Criteria
- Not provided
Outcomes
Primary Outcomes
Long Term Mortality
Time Frame: up to 1 year
Death from any cause 90 day, 1 year
Secondary Outcomes
- Cognitive Dysfunction(Up to 12 months after discharge)
- Functional Status Score(up to 12 months after discharge)
- Hospital length of stay(hospitalization up to 6 weeks)
- hospital mortality(28 day)
- ICU length of stay(hospitalization up to 6 weeks)
- Quality of Life score(up to 12 months after discharge)