The amount of Propofol required for induction of anesthesia when it is given at 1min /3min /5min after injection of fentanyl.

Phase 1

Not yet recruiting

• Conditions: Diseases of esophagus, stomach and duodenum, (2) ICD-10 Condition: H65-H75||Diseases of middle ear and mastoid,

• Registration Number: CTRI/2021/09/036612
• Lead Sponsor: Mumthaz Hashim

Brief Summary

Propofol is the most commonly used intravenous induction agent.

This is a randomized study to examine the effect of varying time intervals  between Fentanyl and Propofol administration (1min, 3min, 5min intervals) on the dose of Propofol required for induction of anesthesia.

Detailed Description

Not available

Study Timeline

• Last Update Posted: 2021-08-31
• Study Start: 2022-01-01

Recruitment & Eligibility

• Status: Not Yet Recruiting
• Sex: All
• Target Recruitment: 90

Inclusion Criteria

• American Society of Anesthesiologists (ASA) physical status I and II 2.
• Patients undergoing any elective surgeries under General Anesthesia 3.
• Patients giving informed valid written consent.

Exclusion Criteria

• Patients refusing to give consent 2.
• Patients posted for emergency surgeries 3.
• Patients with anticipated or actual difficult airway 4.
• Patients with cardiac, renal, hepatic, cerebral diseases 5.
• Patients allergic to Propofol and / or fentanyl 6.
• Patients with BMI <18kg/m2 and > 30kg/m2 7.
• Patients with alcohol intake and drug (enzyme inducer) use.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
To measure the total dose of Propofol required for induction of anesthesia following administration of Fentanyl at varying time intervals.	Dose of Propofol required will be measured at the end of 1min, 3min and 5min.

Secondary Outcome Measures

Name	Time	Method
To evaluate the effect of varying time intervals between administration of Fentanyl and Propofol on hemodynamic variables such as hear rate, Systolic BP, Diastolic BP and Mean Arterial Pressure.	HR, SBP, DBP, MAP, spo2 measured every minute upto 10 minutes.

Trial Locations

Locations (1)

Department of Anesthesiology; 🇮🇳 Dharwad, KARNATAKA, India

Department of Anesthesiology

🇮🇳Dharwad, KARNATAKA, India

Mumthaz Hashim

Principal investigator

7403256710

mumthazhashim04@gmail.com