Rehearsal-Induced Memory Consolidation and Its Modulation by Sleep in People With Epilepsy
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 20
- 试验地点
- 1
- 主要终点
- Change in the percentage of object categories recalled (vs. not recalled) between immediate (30 min after learning) and delayed (12h after learning) recall for rehearsed versus non-rehearsed items.
研究概览
简要总结
Memory consolidation transforms unstable memory traces into lasting representations, a process enhanced by both sleep and rehearsal during learning. Rehearsal is thought to accelerate consolidation by inducing memory reactivations that resemble those occurring during sleep. However, the respective mechanisms of sleep- and rehearsal-induced consolidation-and their potential interactions-remain poorly understood, especially in patients with temporal lobe epilepsy, where rehearsal might help compensate for memory deficits linked to hippocampal dysfunction, and where sleep may exacerbate epileptic activity. The CORESOM-EPI study aims to compare the effects of rehearsal and sleep on memory consolidation in patients undergoing video-EEG monitoring. Participants will learn "object-place" associations under two conditions (single versus repeated encoding), with memory tested immediately and again after a 12-hour delay. This delay will either include a full day awake or a night of sleep, allowing direct comparison of sleep- and rehearsal-related consolidation effects. Each participant will perform the task twice, with "wake" and "sleep" condition, in a balanced order. As a preliminary phase of the CRIMES study (ANR-DFG 2024), CORESOM-EPI will help assess how sleep and rehearsal influence memory consolidation in epilepsy. It will also serve to adapt the behavioral task for clinical use, paving the way for a future intracranial EEG investigations that will explore the neural networks involved and their modulation by epileptic activity.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patient with epilepsy (any type of epilepsy)
- •Hospitalized for video-EEG recording lasting at least 4 days
- •Aged 18-65 years
排除标准
- •Major cognitive impairment other than memory deficit
- •Refusal to participate
- •Pregnant women, women in labor or nursing mothers
- •Persons deprived of their liberty by judicial or administrative decision
- •Persons under psychiatric care
- •Persons admitted to a health or social institution for purposes other than research
- •Adults under legal protection (guardianship, curatorship)
研究组 & 干预措施
WAKE - SLEEP
This group will start with the condition 1 " wake " (encoding+immediate recall in the morning (8 :00am) and delayed recall in the evening (8 :00pm)) and will end with the condition 2 " sleep " : (encoding+immediate recall in the evening (8 :00pm) and delayed recall in the morning (8 :00am))
干预措施: Cognitive memory task on a computer (Other)
WAKE - SLEEP
This group will start with the condition 1 " wake " (encoding+immediate recall in the morning (8 :00am) and delayed recall in the evening (8 :00pm)) and will end with the condition 2 " sleep " : (encoding+immediate recall in the evening (8 :00pm) and delayed recall in the morning (8 :00am))
干预措施: Eye tracking (Other)
WAKE - SLEEP
This group will start with the condition 1 " wake " (encoding+immediate recall in the morning (8 :00am) and delayed recall in the evening (8 :00pm)) and will end with the condition 2 " sleep " : (encoding+immediate recall in the evening (8 :00pm) and delayed recall in the morning (8 :00am))
干预措施: Questionnaires on task-related fatigue (Other)
WAKE - SLEEP
This group will start with the condition 1 " wake " (encoding+immediate recall in the morning (8 :00am) and delayed recall in the evening (8 :00pm)) and will end with the condition 2 " sleep " : (encoding+immediate recall in the evening (8 :00pm) and delayed recall in the morning (8 :00am))
干预措施: Questionnaire on task difficulty (Other)
WAKE - SLEEP
This group will start with the condition 1 " wake " (encoding+immediate recall in the morning (8 :00am) and delayed recall in the evening (8 :00pm)) and will end with the condition 2 " sleep " : (encoding+immediate recall in the evening (8 :00pm) and delayed recall in the morning (8 :00am))
干预措施: Karolinska scale (Other)
SLEEP-WAKE
This group will start with the condition 2 " sleep "and will end with the condition 1 " wake "
干预措施: Cognitive memory task on a computer (Other)
SLEEP-WAKE
This group will start with the condition 2 " sleep "and will end with the condition 1 " wake "
干预措施: Eye tracking (Other)
SLEEP-WAKE
This group will start with the condition 2 " sleep "and will end with the condition 1 " wake "
干预措施: Questionnaires on task-related fatigue (Other)
SLEEP-WAKE
This group will start with the condition 2 " sleep "and will end with the condition 1 " wake "
干预措施: Questionnaire on task difficulty (Other)
SLEEP-WAKE
This group will start with the condition 2 " sleep "and will end with the condition 1 " wake "
干预措施: Karolinska scale (Other)
结局指标
主要结局
Change in the percentage of object categories recalled (vs. not recalled) between immediate (30 min after learning) and delayed (12h after learning) recall for rehearsed versus non-rehearsed items.
时间窗: Day 2 + 48 hours
The impact of rehearsal on object category recognition in an object-place learning paradigm is assessed. For the primary outcome, data from the 2 conditions ("wake" and "sleep" during the 12h period between immediate and delayed recall) will be pooled. Each participant will take part in the wake and sleep condition over 4 days (2 conditions separated by at least 24h), in a balanced order between participants.
Change in the percentage of object categories recalled (vs. not recalled) between immediate (30 min after learning) and delayed (12h after learning) recall for rehearsed versus non-rehearsed items.
时间窗: Day 2
The impact of rehearsal on object category recognition in an object-place learning paradigm is assessed. For the primary outcome, data from the 2 conditions ("wake" and "sleep" during the 12h period between immediate and delayed recall) will be pooled. Each participant will take part in the wake and sleep condition over 4 days (2 conditions separated by at least 24h), in a balanced order between participants.
Change in the percentage of object categories recalled (vs. not recalled) between immediate (30 min after learning) and delayed (12h after learning) recall for rehearsed versus non-rehearsed items.
时间窗: Day 2 + 12 hours
The impact of rehearsal on object category recognition in an object-place learning paradigm is assessed. For the primary outcome, data from the 2 conditions ("wake" and "sleep" during the 12h period between immediate and delayed recall) will be pooled. Each participant will take part in the wake and sleep condition over 4 days (2 conditions separated by at least 24h), in a balanced order between participants.
Change in the percentage of object categories recalled (vs. not recalled) between immediate (30 min after learning) and delayed (12h after learning) recall for rehearsed versus non-rehearsed items.
时间窗: Day 2 + 36 hours
The impact of rehearsal on object category recognition in an object-place learning paradigm is assessed. For the primary outcome, data from the 2 conditions ("wake" and "sleep" during the 12h period between immediate and delayed recall) will be pooled. Each participant will take part in the wake and sleep condition over 4 days (2 conditions separated by at least 24h), in a balanced order between participants.
次要结局
未报告次要终点