TO SEE THE EFFECTS OF LOW BODY TEMPERATURE AND DURATION OF HEART-LUNG BYPASS ON OXYGEN SUPPLY OF BRAIN AS SHOWN BY A SPECIAL MONITOR-NIRS
Not Applicable
- Registration Number
- CTRI/2018/10/015909
- Lead Sponsor
- DR Ram Manohar Lohia Institute Of Medical Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot Yet Recruiting
- Sex
- Not specified
- Target Recruitment
- 0
Inclusion Criteria
1.Informed written consent.
2.Patients between 18-60 years of age of either sex.
3.Patients undergoing open heart surgeries on cardio pulmonary bypass.
Exclusion Criteria
1.Patient’s refusal to participate in the study.
2.Patients with pre-existing neurocognitive dysfunction.
3.Patients with a history of symptomatic cerebrovascular disease.
4.Deep hypothermic cardiac arrest.
5.CPB temperature less than 28?.
6.Anaemia with haematocrit <21%.
7.Patients with atheromatous plaque in carotid arteries, stenosis of carotid arteries, clot in left atrium or left ventricle.
Study & Design
- Study Type
- Observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method To see the effect of temperature and duration of cardiopulmonary bypass on cerebral saturation(rScO2) using NIRSTimepoint: Time points of measurement of rScO2: <br/ ><br>1.Before induction(BI) <br/ ><br>2.15 minutes after induction <br/ ><br>3.On CPB, every 5 minutes <br/ ><br>4.Immediate post CPB <br/ ><br>5.At arrival in post operative ICU <br/ ><br>
- Secondary Outcome Measures
Name Time Method 2.To see the clinical correlation of neurological outcomes in post operative period with cerebral saturation in the intra-operative period.Timepoint: OUTCOME VARIABLES- <br/ ><br>1. Clinical diagnosis of stroke or encephalopathy; <br/ ><br>2. Western Perioperative Neurologic Scale (WPNS). <br/ ><br>3.Trail making Test A (TTA) 4. Mini Mental State Examination (MMSE). <br/ ><br> <br/ ><br>Time points for measurement of neurocognitive functions: <br/ ><br>1. Pre-operative <br/ ><br>2. Post-extubation <br/ ><br>3. 24 hrs post-extubation <br/ ><br>4. On the day of discharge <br/ ><br>5. One month after surgery <br/ ><br>6. Six months after surgery <br/ ><br> <br/ ><br> <br/ ><br>