Description of Physical Activity Effect on Neuromuscular Fatigue of Older People
Trial Snapshot
- Phase
- Not Applicable
- Status
- Terminated
- Enrollment
- 93
- Locations
- 1
- Primary Endpoint
- Maximal voluntary contraction (MVC) of the knee extensor muscle measurement
Study Overview
Brief Summary
There is a decrease in cardiovascular and neuromuscular functions, which leads to reduced performance with advancing age. Physical activity provides health benefits, prevents and treats cardiovascular and neuromuscular disease. The aim of this project is to describe cardiovascular and neuromuscular function in active and sedentary subjects of different ages.
Detailed Description
With advancing age, there is a decrease in cardiovascular and neuromuscular functions, which leads to reduced performance and increases the likelihood that older people will lose their independence. Physical activity provides health benefits, prevents and treats cardiovascular and neuromuscular disease. Indeed, recent data support the idea that it is fitness level, not age that explains physiological responses to exercise. However, although there are data about how quickly cardiovascular and neuromuscular functions decline throughout life, less is known on the extent physical activity can help mitigate the loss of these functions. The aim of this project is therefore to describe cardiovascular and neuromuscular function in active and sedentary subjects of different ages.
Study Design
- Study Type
- Interventional
- Allocation
- Non Randomized
- Intervention Model
- Parallel
- Primary Purpose
- Prevention
- Masking
- None
Eligibility Criteria
- Ages
- 18 Years to — (Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- Yes
Inclusion Criteria
- •Aged 18 to 35 for the young group, between 65 and 80 for the old group and over 80 for the very old group.
- •Signed consent for the study obtained
- •Subject affiliated or entitled to a social security scheme
Exclusion Criteria
- •Pathology or surgical intervention causing a locomotor disorder
- •Neurological, cardiovascular or psychological pathology
- •Participants will be excluded if resting or exercise ECG responses show any abnormality, or if resting Heart Rate (HR) > 100 bmp, resting blood pressure > 144 (systolic) / 95 (diastolic) mmHg, pulmonary and or cardiac disease that could affect the health of the participant (arrhythmias and stroke)
- •Mini-Mental State Examination score < 20 (>80 years old)
- •Significant change in the amount of physical practice over the last 5 years.
Arms & Interventions
Young, Active group
From 18 to 35 years old.
The subjects will be considered as active if after completion of the Global Physical Activity Questionnaire (GPAQ), the subjects count:
- at least 20 minutes of vigorous physical activity per day for 3 or more days per week OR
- at least 30 minutes of moderate physical activity or walking per day for 5 or more days per week OR
- At least 5 days of walking and moderate or vigorous physical activity, reaching a minimum of 600 Metabolic Equivalent of Task (MET)-minutes per week
Intervention: Questionnaires completion (Other)
Young, Active group
From 18 to 35 years old.
The subjects will be considered as active if after completion of the Global Physical Activity Questionnaire (GPAQ), the subjects count:
- at least 20 minutes of vigorous physical activity per day for 3 or more days per week OR
- at least 30 minutes of moderate physical activity or walking per day for 5 or more days per week OR
- At least 5 days of walking and moderate or vigorous physical activity, reaching a minimum of 600 Metabolic Equivalent of Task (MET)-minutes per week
Intervention: Isometric forces (Other)
Young, Active group
From 18 to 35 years old.
The subjects will be considered as active if after completion of the Global Physical Activity Questionnaire (GPAQ), the subjects count:
- at least 20 minutes of vigorous physical activity per day for 3 or more days per week OR
- at least 30 minutes of moderate physical activity or walking per day for 5 or more days per week OR
- At least 5 days of walking and moderate or vigorous physical activity, reaching a minimum of 600 Metabolic Equivalent of Task (MET)-minutes per week
Intervention: Energy cost (Other)
Young, sedentary group
From 18 to 35 years old. Subjects who are below these thresholds will be considered as sedentary. To avoid including a subject who recently changed his lifestyle (sedentary becoming active or vice versa), the investigator will ensure the subject kept this physical activity level (expressed using the GPAQ) constant for the last 5 years.
Intervention: Questionnaires completion (Other)
Young, sedentary group
From 18 to 35 years old. Subjects who are below these thresholds will be considered as sedentary. To avoid including a subject who recently changed his lifestyle (sedentary becoming active or vice versa), the investigator will ensure the subject kept this physical activity level (expressed using the GPAQ) constant for the last 5 years.
Intervention: Isometric forces (Other)
Young, sedentary group
From 18 to 35 years old. Subjects who are below these thresholds will be considered as sedentary. To avoid including a subject who recently changed his lifestyle (sedentary becoming active or vice versa), the investigator will ensure the subject kept this physical activity level (expressed using the GPAQ) constant for the last 5 years.
Intervention: Energy cost (Other)
Old, Active group
From 65 to 80 years old.
The subjects will be considered as active if after completion of the Global Physical Activity Questionnaire (GPAQ), the subjects count:
- at least 20 minutes of vigorous physical activity per day for 3 or more days per week OR
- at least 30 minutes of moderate physical activity or walking per day for 5 or more days per week OR
- At least 5 days of walking and moderate or vigorous physical activity, reaching a minimum of 600 MET-minutes per week
Intervention: Questionnaires completion (Other)
Old, Active group
From 65 to 80 years old.
The subjects will be considered as active if after completion of the Global Physical Activity Questionnaire (GPAQ), the subjects count:
- at least 20 minutes of vigorous physical activity per day for 3 or more days per week OR
- at least 30 minutes of moderate physical activity or walking per day for 5 or more days per week OR
- At least 5 days of walking and moderate or vigorous physical activity, reaching a minimum of 600 MET-minutes per week
Intervention: Isometric forces (Other)
Old, Active group
From 65 to 80 years old.
The subjects will be considered as active if after completion of the Global Physical Activity Questionnaire (GPAQ), the subjects count:
- at least 20 minutes of vigorous physical activity per day for 3 or more days per week OR
- at least 30 minutes of moderate physical activity or walking per day for 5 or more days per week OR
- At least 5 days of walking and moderate or vigorous physical activity, reaching a minimum of 600 MET-minutes per week
Intervention: Energy cost (Other)
Old sedentary group
From 65 to 80 years old. Subjects who are below these thresholds will be considered as sedentary. To avoid including a subject who recently changed his lifestyle (sedentary becoming active or vice versa), the investigator will ensure the subject kept this physical activity level (expressed using the GPAQ) constant for the last 5 years.
Intervention: Questionnaires completion (Other)
Old sedentary group
From 65 to 80 years old. Subjects who are below these thresholds will be considered as sedentary. To avoid including a subject who recently changed his lifestyle (sedentary becoming active or vice versa), the investigator will ensure the subject kept this physical activity level (expressed using the GPAQ) constant for the last 5 years.
Intervention: Isometric forces (Other)
Old sedentary group
From 65 to 80 years old. Subjects who are below these thresholds will be considered as sedentary. To avoid including a subject who recently changed his lifestyle (sedentary becoming active or vice versa), the investigator will ensure the subject kept this physical activity level (expressed using the GPAQ) constant for the last 5 years.
Intervention: Energy cost (Other)
Very old, Active group
From 81 years old.
The subjects will be considered as active if after completion of the Global Physical Activity Questionnaire (GPAQ), the subjects count:
- at least 20 minutes of vigorous physical activity per day for 3 or more days per week OR
- at least 30 minutes of moderate physical activity or walking per day for 5 or more days per week OR
- At least 5 days of walking and moderate or vigorous physical activity, reaching a minimum of 600 MET-minutes per week
Intervention: Questionnaires completion (Other)
Very old, Active group
From 81 years old.
The subjects will be considered as active if after completion of the Global Physical Activity Questionnaire (GPAQ), the subjects count:
- at least 20 minutes of vigorous physical activity per day for 3 or more days per week OR
- at least 30 minutes of moderate physical activity or walking per day for 5 or more days per week OR
- At least 5 days of walking and moderate or vigorous physical activity, reaching a minimum of 600 MET-minutes per week
Intervention: Isometric forces (Other)
Very old, Active group
From 81 years old.
The subjects will be considered as active if after completion of the Global Physical Activity Questionnaire (GPAQ), the subjects count:
- at least 20 minutes of vigorous physical activity per day for 3 or more days per week OR
- at least 30 minutes of moderate physical activity or walking per day for 5 or more days per week OR
- At least 5 days of walking and moderate or vigorous physical activity, reaching a minimum of 600 MET-minutes per week
Intervention: Energy cost (Other)
Very old sedentary group
From 81 years old. Subjects who are below these thresholds will be considered as sedentary. To avoid including a subject who recently changed his lifestyle (sedentary becoming active or vice versa), the investigator will ensure the subject kept this physical activity level (expressed using the GPAQ) constant for the last 5 years.
Intervention: Questionnaires completion (Other)
Very old sedentary group
From 81 years old. Subjects who are below these thresholds will be considered as sedentary. To avoid including a subject who recently changed his lifestyle (sedentary becoming active or vice versa), the investigator will ensure the subject kept this physical activity level (expressed using the GPAQ) constant for the last 5 years.
Intervention: Isometric forces (Other)
Very old sedentary group
From 81 years old. Subjects who are below these thresholds will be considered as sedentary. To avoid including a subject who recently changed his lifestyle (sedentary becoming active or vice versa), the investigator will ensure the subject kept this physical activity level (expressed using the GPAQ) constant for the last 5 years.
Intervention: Energy cost (Other)
Outcomes
Primary Outcomes
Maximal voluntary contraction (MVC) of the knee extensor muscle measurement
Time Frame: At 48 hours
Maximal isometric force (maximal voluntary contraction, MVC) of the knee extensor muscle measured before and after an incremental test on a bicycle ergometer
Secondary Outcomes
- Maximal oxygen consumption (VO2max) during an effort test on a cycloergometer(At 72 hours)
- Cardiac variability(ms)(At 48 hours)
- Muscle oxygenation (%)(At 48 hours)
- Test of Get-up-and-Go (s)(At 48 hours)
- Maximal voluntary contraction (MVC) of the hand grip measurement(At 48 hours)
- Voluntary activation measurement (%)(At 48 hours)
- Maximal voluntary contraction (MVC) of the plantar flexor muscle measurement(At 48 hours)
- Balance test (s)(At 48 hours)
- Reaction force on the ground for each step (N)(At 72 hours)
- Functional Assessment of Chronic Illness Therapy (FACIT) questionnaire(At inclusion)
- Quality of life via the SF-36 questionnaire(At inclusion)