Effect of physical activity on brain-derived neurotrophic factor – Association with cognitive dysfunction in depression. An explorative study - BDNF-Pilot Study

niversitätsklinikum Heidelberg, Zentrum für psychosoziale Medizin, Klinik für allgemeine Psychiatrie, Arbeitsgruppe Neurokognition0 sites41 target enrollmentAugust 3, 2018

ConditionsF32.1 F34 Moderate depressive episode Persistent mood [affective] disorders

Overview

Phase: N/A
Intervention: Not specified
Conditions: F32.1
Sponsor: niversitätsklinikum Heidelberg, Zentrum für psychosoziale Medizin, Klinik für allgemeine Psychiatrie, Arbeitsgruppe Neurokognition
Enrollment: 41
Status: Completed
Last Updated: last year

Overview Investigators Eligibility Criteria Outcomes Similar Trials

Overview

Brief Summary

No summary available.

Registry

who.int

Start Date

August 3, 2018

End Date

August 1, 2020

Last Updated

last year

Study Type

Interventional

Sex

All

Investigators

Sponsor

niversitätsklinikum Heidelberg, Zentrum für psychosoziale Medizin, Klinik für allgemeine Psychiatrie, Arbeitsgruppe Neurokognition

Eligibility Criteria

Inclusion Criteria

•(1\)Outpatients with a current or past\-time diagnosis of major depressive disorder
•(2\)Age between 18 and 60 years
•(3\)IQ\>80 according to the Mehrfachwahl\-Wortschatztest B (MWT\-B)
•(4\)Clinically stable patients who are able to provide informed consent
•(5\)Subjective Cognitive Complaints

Exclusion Criteria

•(1\)Psychiatric co\-morbidities as identified by mini international neuropsychiatric interview: current substance (alcohol or drug) abuse and dependence, current or lifetime psychotic disorder and mania, current anorexia, bulimia, PTSD, and panic disorder
•(2\)Reported current or chronic neurological disorders
•(3\)Patients with Hamilton Rating Scale for Depression (HAMD\-21\) scores \= 20 will be excluded to avoid confounding with severe depressive symptoms.
•(4\)Physical fitness: Patients with somatic conditions presenting a risk to the graded exercise test will be excluded, e.g., unstable angina pectoris, symptomatic arrhythmia, symptomatic aortic stenosis, heart failure, acute pulmonary embolism, acute myocarditis, acute pericarditis, acute aortic dissection, high grade coronary artery disease, uncontrolled hypertension (RR\>200/110mmHg), hypertrophic cardiomyopathy, endocarditis, symptomatic congenital and acquired heart defects. Furthermore, patients who cannot sufficiently participate in the graded exercise test due to health issues, e.g. COPD, severe asthma, current severe allergies, severe obesity (bodyweight \>180kg, weight limit of the stationary bicycle), orthopedic disabilities will be excluded.