Description of Physical Activity Effect on Neuromuscular Fatigue of Older People
- Conditions
- FatigueAging
- Interventions
- Other: Questionnaires completionOther: Isometric forcesOther: Energy cost
- Registration Number
- NCT05413590
- Brief Summary
There is a decrease in cardiovascular and neuromuscular functions, which leads to reduced performance with advancing age. Physical activity provides health benefits, prevents and treats cardiovascular and neuromuscular disease. The aim of this project is to describe cardiovascular and neuromuscular function in active and sedentary subjects of different ages.
- Detailed Description
With advancing age, there is a decrease in cardiovascular and neuromuscular functions, which leads to reduced performance and increases the likelihood that older people will lose their independence. Physical activity provides health benefits, prevents and treats cardiovascular and neuromuscular disease. Indeed, recent data support the idea that it is fitness level, not age that explains physiological responses to exercise. However, although there are data about how quickly cardiovascular and neuromuscular functions decline throughout life, less is known on the extent physical activity can help mitigate the loss of these functions. The aim of this project is therefore to describe cardiovascular and neuromuscular function in active and sedentary subjects of different ages.
Recruitment & Eligibility
- Status
- RECRUITING
- Sex
- All
- Target Recruitment
- 180
- Aged 18 to 35 for the young group, between 65 and 80 for the old group and over 80 for the very old group.
- Signed consent for the study obtained
- Subject affiliated or entitled to a social security scheme
- Pathology or surgical intervention causing a locomotor disorder
- Neurological, cardiovascular or psychological pathology
- Participants will be excluded if resting or exercise ECG responses show any abnormality, or if resting Heart Rate (HR) > 100 bmp, resting blood pressure > 144 (systolic) / 95 (diastolic) mmHg, pulmonary and or cardiac disease that could affect the health of the participant (arrhythmias and stroke)
- Mini-Mental State Examination score < 20 (>80 years old)
- Significant change in the amount of physical practice over the last 5 years.
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Old, Active group Energy cost From 65 to 80 years old. The subjects will be considered as active if after completion of the Global Physical Activity Questionnaire (GPAQ), the subjects count: * at least 20 minutes of vigorous physical activity per day for 3 or more days per week OR * at least 30 minutes of moderate physical activity or walking per day for 5 or more days per week OR * At least 5 days of walking and moderate or vigorous physical activity, reaching a minimum of 600 MET-minutes per week Old sedentary group Isometric forces From 65 to 80 years old. Subjects who are below these thresholds will be considered as sedentary. To avoid including a subject who recently changed his lifestyle (sedentary becoming active or vice versa), the investigator will ensure the subject kept this physical activity level (expressed using the GPAQ) constant for the last 5 years. Young, Active group Isometric forces From 18 to 35 years old. The subjects will be considered as active if after completion of the Global Physical Activity Questionnaire (GPAQ), the subjects count: * at least 20 minutes of vigorous physical activity per day for 3 or more days per week OR * at least 30 minutes of moderate physical activity or walking per day for 5 or more days per week OR * At least 5 days of walking and moderate or vigorous physical activity, reaching a minimum of 600 Metabolic Equivalent of Task (MET)-minutes per week Young, sedentary group Energy cost From 18 to 35 years old. Subjects who are below these thresholds will be considered as sedentary. To avoid including a subject who recently changed his lifestyle (sedentary becoming active or vice versa), the investigator will ensure the subject kept this physical activity level (expressed using the GPAQ) constant for the last 5 years. Old, Active group Questionnaires completion From 65 to 80 years old. The subjects will be considered as active if after completion of the Global Physical Activity Questionnaire (GPAQ), the subjects count: * at least 20 minutes of vigorous physical activity per day for 3 or more days per week OR * at least 30 minutes of moderate physical activity or walking per day for 5 or more days per week OR * At least 5 days of walking and moderate or vigorous physical activity, reaching a minimum of 600 MET-minutes per week Old sedentary group Questionnaires completion From 65 to 80 years old. Subjects who are below these thresholds will be considered as sedentary. To avoid including a subject who recently changed his lifestyle (sedentary becoming active or vice versa), the investigator will ensure the subject kept this physical activity level (expressed using the GPAQ) constant for the last 5 years. Young, Active group Questionnaires completion From 18 to 35 years old. The subjects will be considered as active if after completion of the Global Physical Activity Questionnaire (GPAQ), the subjects count: * at least 20 minutes of vigorous physical activity per day for 3 or more days per week OR * at least 30 minutes of moderate physical activity or walking per day for 5 or more days per week OR * At least 5 days of walking and moderate or vigorous physical activity, reaching a minimum of 600 Metabolic Equivalent of Task (MET)-minutes per week Young, Active group Energy cost From 18 to 35 years old. The subjects will be considered as active if after completion of the Global Physical Activity Questionnaire (GPAQ), the subjects count: * at least 20 minutes of vigorous physical activity per day for 3 or more days per week OR * at least 30 minutes of moderate physical activity or walking per day for 5 or more days per week OR * At least 5 days of walking and moderate or vigorous physical activity, reaching a minimum of 600 Metabolic Equivalent of Task (MET)-minutes per week Young, sedentary group Questionnaires completion From 18 to 35 years old. Subjects who are below these thresholds will be considered as sedentary. To avoid including a subject who recently changed his lifestyle (sedentary becoming active or vice versa), the investigator will ensure the subject kept this physical activity level (expressed using the GPAQ) constant for the last 5 years. Young, sedentary group Isometric forces From 18 to 35 years old. Subjects who are below these thresholds will be considered as sedentary. To avoid including a subject who recently changed his lifestyle (sedentary becoming active or vice versa), the investigator will ensure the subject kept this physical activity level (expressed using the GPAQ) constant for the last 5 years. Old, Active group Isometric forces From 65 to 80 years old. The subjects will be considered as active if after completion of the Global Physical Activity Questionnaire (GPAQ), the subjects count: * at least 20 minutes of vigorous physical activity per day for 3 or more days per week OR * at least 30 minutes of moderate physical activity or walking per day for 5 or more days per week OR * At least 5 days of walking and moderate or vigorous physical activity, reaching a minimum of 600 MET-minutes per week Old sedentary group Energy cost From 65 to 80 years old. Subjects who are below these thresholds will be considered as sedentary. To avoid including a subject who recently changed his lifestyle (sedentary becoming active or vice versa), the investigator will ensure the subject kept this physical activity level (expressed using the GPAQ) constant for the last 5 years. Very old, Active group Questionnaires completion From 81 years old. The subjects will be considered as active if after completion of the Global Physical Activity Questionnaire (GPAQ), the subjects count: * at least 20 minutes of vigorous physical activity per day for 3 or more days per week OR * at least 30 minutes of moderate physical activity or walking per day for 5 or more days per week OR * At least 5 days of walking and moderate or vigorous physical activity, reaching a minimum of 600 MET-minutes per week Very old sedentary group Energy cost From 81 years old. Subjects who are below these thresholds will be considered as sedentary. To avoid including a subject who recently changed his lifestyle (sedentary becoming active or vice versa), the investigator will ensure the subject kept this physical activity level (expressed using the GPAQ) constant for the last 5 years. Very old, Active group Isometric forces From 81 years old. The subjects will be considered as active if after completion of the Global Physical Activity Questionnaire (GPAQ), the subjects count: * at least 20 minutes of vigorous physical activity per day for 3 or more days per week OR * at least 30 minutes of moderate physical activity or walking per day for 5 or more days per week OR * At least 5 days of walking and moderate or vigorous physical activity, reaching a minimum of 600 MET-minutes per week Very old, Active group Energy cost From 81 years old. The subjects will be considered as active if after completion of the Global Physical Activity Questionnaire (GPAQ), the subjects count: * at least 20 minutes of vigorous physical activity per day for 3 or more days per week OR * at least 30 minutes of moderate physical activity or walking per day for 5 or more days per week OR * At least 5 days of walking and moderate or vigorous physical activity, reaching a minimum of 600 MET-minutes per week Very old sedentary group Questionnaires completion From 81 years old. Subjects who are below these thresholds will be considered as sedentary. To avoid including a subject who recently changed his lifestyle (sedentary becoming active or vice versa), the investigator will ensure the subject kept this physical activity level (expressed using the GPAQ) constant for the last 5 years. Very old sedentary group Isometric forces From 81 years old. Subjects who are below these thresholds will be considered as sedentary. To avoid including a subject who recently changed his lifestyle (sedentary becoming active or vice versa), the investigator will ensure the subject kept this physical activity level (expressed using the GPAQ) constant for the last 5 years.
- Primary Outcome Measures
Name Time Method Maximal voluntary contraction (MVC) of the knee extensor muscle measurement At 48 hours Maximal isometric force (maximal voluntary contraction, MVC) of the knee extensor muscle measured before and after an incremental test on a bicycle ergometer
- Secondary Outcome Measures
Name Time Method Maximal oxygen consumption (VO2max) during an effort test on a cycloergometer At 72 hours Cardiac variability(ms) At 48 hours 24-hour measurement with an ECG holter for 24 hours.
Muscle oxygenation (%) At 48 hours This is measured by a NIRS20 (near infrared spectroscopy, Oxysoft, Artinis, TheNetherlands)
Test of Get-up-and-Go (s) At 48 hours For test of Get-up-and-Go, participants will be asked to stand from a seated position, walk 3 meters at their usual pace, turn around, walk back to the chair, and sit down.
Measured in seconds when performing test.Maximal voluntary contraction (MVC) of the hand grip measurement At 48 hours Maximal isometric force (maximal voluntary contraction, MVC) of the knee extensor muscle measured before and after an incremental test on a bicycle ergometer
Voluntary activation measurement (%) At 48 hours The level of voluntary activation will be determined by the force increment obtained following stimulation performed during a condition of the muscle in a state of maximum contraction.
Maximal voluntary contraction (MVC) of the plantar flexor muscle measurement At 48 hours Maximal isometric force (maximal voluntary contraction, MVC) of the knee extensor muscle measured before and after an incremental test on a bicycle ergometer
Balance test (s) At 48 hours This test, performed in unipedal support, consists of asking the subject to hold the unipedal position for as long as possible, on the lower limb of his choice.
Reaction force on the ground for each step (N) At 72 hours First, a maximum pace walking speed and a comfort speed will be measured in a corridor using photoelectric cells. Then, a biomechanical analysis of walking at several speeds (comfort walking, 2.5, 4 and 5.5 km/h) will be performed on an instrumented treadmill (Treadmetrix, Park City, Utah, United States). This treadmill allows the analysis of the reaction forces on the ground during the strides while controlling the speed of the walk. Each step will last approximately 30 seconds.
Functional Assessment of Chronic Illness Therapy (FACIT) questionnaire At inclusion Score from 0 to 52
Quality of life via the SF-36 questionnaire At inclusion This questionnaire is composed of 12 questions representing the eight most relevant domains to describe and evaluate quality of life. Score ranges from 0 to 100, with a higher score defining a more favorable health state.
Trial Locations
- Locations (1)
Chu de Saint-Etienne
🇫🇷Saint-Étienne, France