The effect of lowered physical activity (induced by unilateral lower limb suspension (ULLS)) on insulin sensitivity and lipid and glucose metabolism

Completed

Conditions: Skeletal muscle metabolism
The metabolic process of the skeletal muscle

Registration Number: NL-OMON37695

Lead Sponsor: niversiteit Maastricht

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Completed

Sex: Not specified

Target Recruitment: 22

Inclusion Criteria

Men between 18-35 years of age at time of enrolment
Non smoking
No recent bone fractures of the limbs
No cardiovascular medication or other medication
No (family) history of thrombosis
No engagement in programmed exercise for more than two hours a week
Stable dietary habits
No contra-indication for MRI

Exclusion Criteria

Regular smokers
Participation in other studies
Female sex
Recent bone fractures of the limbs
Medication use
Cardiovascular disease
(Family) history of thrombosis
Contraindications for MRI scans:
• Electronic implants such as pacemaker or neurostimulator
• Iron-containing foreign bodies in eyes or brain
• Some hearing aids and artificial (heart) valves which are contraindicated for MRI
• Claustrophobia
Participants, who do not want to be informed about unexpected medical findings, or do not wish that their physician will be informed, cannot participate in the study

Study & Design

Study Type: Interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p> The main study parameters are the effects of lowered physical activity<br /><br>(resulting in decreased muscle mitochondrial oxidative capacity) on insulin<br /><br>sensitivity, lipid/glucose metabolism and intramyocellular lipid content. </p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Other study parameters:<br /><br>- Muscle strength test<br /><br>- Maximal whole body aerobic capacity (VO2max)<br /><br>- Body composition (DEXA)<br /><br>- Blood plasma levels of FFA, triglycerides and glucose<br /><br>- Leg circumference/Volume/ of quadriceps muscle<br /><br>- Leg skin temperature<br /><br>- Activity level (accelerometers)</p><br>