The effect of low intensity physical activity on insulin sensitivity; an exploratory study into a possible link between insulin sensitivity and mood and cognitive performance
- Conditions
- blood sugar valuesinsulin sensitivity10018424
- Registration Number
- NL-OMON42156
- Lead Sponsor
- niversiteit Maastricht
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 27
o Signed informed consent
o Men and postmenopausal women: 40-80 years old
o BMI: 25.0 - 35.0 kg/m2
o Maximum 2.5 hours of MVPA per week (during last 3 months)
o Having a general practitioner
o Agreeing to be informed about medically relevant personal test-results by a physician
o Accessible veins on arms as determined by examination at screening
o Reported participation in another biomedical trial which may have an effect on insulin sensitivity one month before the pre-study examination or during the study
o Blood donation in the past three months
o Reported participation in night shift work 2 weeks prior to pre-study investigation or during the study. Night work is defined as working between midnight and 6.00 AM.
o Consumption of >14 (women) or > 21 (men) alcoholic units per week
o Reported dietary habits: medically prescribed diet, slimming diet;
o Reported weight loss (>2kg) in the last three months prior to the screening;
o Not being able to execute at least three (out of four) cognition tests in the training session
o Not being able to execute the sit less try-out day
o Being an employee of Unilever or the collaborating research departments in Maastricht University Medical Centre
o Experimental drug use (during the last 3 months)
o Use of insulin, oral blood glucose lowering medication (metformin and/or SU-derivatives and/or DPP-IV inhibitors), corticosteroids or vitamin K antagonists in the last 3 months
o Fasting plasma glucose level > 6.9 mmol/L
o Medical conditions which make participation in the study not responsible which will be decided by a medical doctor during screening
o Other clinically relevant abnormalities in clinical chemistry at screening (to be judged by a medical doctor)
o Mental or physical disability which interferes with physical activity
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>• To assess the effect of low intensity physical activity (LIPA) on plasma<br /><br>insulin levels (as measured as area under the curve during an oral glucose<br /><br>tolerance test)</p><br>
- Secondary Outcome Measures
Name Time Method <p>Secondary objectives:<br /><br>• To assess the effect of LIPA on insulin sensitivity<br /><br>• To assess the effect of LIPA on plasma C-peptide and glucose levels<br /><br>• To assess the effect of LIPA on lipid metabolism<br /><br>• To assess the effect of LIPA on mood and cognitive performance<br /><br>• To assess the effect of LIPA on Quality of Life and sleep<br /><br>• To explore the association between plasma glucose, plasma insulin, insulin<br /><br>sensitivity and mood, cognitive performance, Quality of Life and sleep<br /><br>• To assess the effect of LIPA on inflammation and endothelium<br /><br>• To assess the effect of LIPA on blood pressure<br /><br>• Insulin like growth factor 1 (IGF-1) and growth hormone (GH)</p><br>