Effect of physical activity on brain-derived neurotrophic factor – Association with cognitive dysfunction in depression. An explorative study

Not Applicable

• Conditions: F32.1; F34; Moderate depressive episode; Persistent mood [affective] disorders

• Registration Number: DRKS00015152
• Lead Sponsor: niversitätsklinikum Heidelberg, Zentrum für psychosoziale Medizin, Klinik für allgemeine Psychiatrie, Arbeitsgruppe Neurokognition

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2018-08-03
• Study Completion: 2020-08-01
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Complete
• Sex: All
• Target Recruitment: 41

Inclusion Criteria

(1)Outpatients with a current or past-time diagnosis of major depressive disorder
(2)Age between 18 and 60 years
(3)IQ>80 according to the Mehrfachwahl-Wortschatztest B (MWT-B)
(4)Clinically stable patients who are able to provide informed consent
(5)Subjective Cognitive Complaints

Exclusion Criteria

(1)Psychiatric co-morbidities as identified by mini international neuropsychiatric interview: current substance (alcohol or drug) abuse and dependence, current or lifetime psychotic disorder and mania, current anorexia, bulimia, PTSD, and panic disorder
(2)Reported current or chronic neurological disorders
(3)Patients with Hamilton Rating Scale for Depression (HAMD-21) scores = 20 will be excluded to avoid confounding with severe depressive symptoms.
(4)Physical fitness: Patients with somatic conditions presenting a risk to the graded exercise test will be excluded, e.g., unstable angina pectoris, symptomatic arrhythmia, symptomatic aortic stenosis, heart failure, acute pulmonary embolism, acute myocarditis, acute pericarditis, acute aortic dissection, high grade coronary artery disease, uncontrolled hypertension (RR>200/110mmHg), hypertrophic cardiomyopathy, endocarditis, symptomatic congenital and acquired heart defects. Furthermore, patients who cannot sufficiently participate in the graded exercise test due to health issues, e.g. COPD, severe asthma, current severe allergies, severe obesity (bodyweight >180kg, weight limit of the stationary bicycle), orthopedic disabilities will be excluded.

Study & Design

• Study Type: interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
BDNF serum concentration in ng/ml, assessed on date of test, before and after physical activity

Secondary Outcome Measures

Name	Time	Method
parameters of cognitive functioning assessed via the test battery COGBAT, assessed on date of test at the end of the procedure