Prochlorperazine vs Imitrex for Acute Migraine in the Emergency Department

Not Applicable

Completed

• Conditions: Acute Migraine Headache
• Interventions: Drug: prochlorperazine and benadryl IV; Drug: Imitrex SubQ, saline IV

• Registration Number: NCT00573599
• Lead Sponsor: United States Naval Medical Center, Portsmouth

Brief Summary

ED patients with acute migraine will be randomized to either prochlorperazine and Bendaryl OR imitrex. VAS for pain will be monitored, along with side effects. Primary outcome measure is improvement in pain scales between the groups.

Detailed Description

Not available

Study Timeline

• Study Start: 2007-02
• Study Completion: 2007-05
• Status Verified: 2007-12
• Study First Submitted: 2007-12-13
• Study First Submitted QC: 2007-12-13
• Last Update Submitted: 2007-12-13
• Study First Posted: 2007-12-14
• Last Update Posted: 2007-12-14

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 66

Inclusion Criteria

• Acute migraine headache

Exclusion Criteria

• Pregnant
• Hypertension
• Chest pain
• < 18
• Allergy to any of the meds

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
1	prochlorperazine and benadryl IV	prochlorperazine and benadryl IV, saline subQ
2	Imitrex SubQ, saline IV	imitrex SubQ, saline IV

Primary Outcome Measures

Name	Time	Method
Difference in pain measured by VAS	80 min

Secondary Outcome Measures

Name	Time	Method
Degree of sedation, nausea, akathisia	80 min

Trial Locations

Locations (1)

Naval Medical Center Portsmouth; 🇺🇸 Portsmouth, Virginia, United States