The Correlation Between Iodine and Selenium Status in Pregnancy and Risk of Thyroid Disease: a Prospective Registry Study
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 290
- 主要终点
- pregnancy outcomes
研究概览
简要总结
Two hundred and ninety pregnant women with gestational age less than 20 weeks will be recruited in this study. Selenium and iodine conditions, and risk of thyroid disease will be monitored until termination of pregnancy, with pregnancy outcomes recorded.
详细描述
The study will recruit 290 pregnant women with gestational age less than 20 weeks. Iodine and selenium condition will be evaluated through dietary recall (on base of Chinese food ingredient information) and biochemical examinations (serum iodine concentrations, urinary iodine concentrations, serum selenium concentrations, etc). The nutritional status of iodine and selenium will be monitored and followed up for all the included subjects throughout the pregnancy. The information of thyroid function and level of anti-TPO and anti-TG will be collected. And all the complications (especially thyroid disease) in pregnancy will also be recorded. All pregnant women will be followed up until the termination of pregnancy, with pregnancy outcomes recorded.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •Clinical confirmation of being pregnant.
- •Being within less than 20 weeks of gestationa.
排除标准
- •Being pregnant but over 20 weeks of gestationa.
- •Mentally or psychologically unstable.
结局指标
主要结局
pregnancy outcomes
时间窗: From date of participant inclusion until the date of termination of pregnancy, assessed up to 8 months
prevalence of premature birth, stillbirth and abortion
risk of thyroid disease
时间窗: From date of participant inclusion until the date of termination of pregnancy, assessed up to 8 months
prevalence of thyroid disease (abnormal thyroid function; development of thyroid antibodies)
次要结局
- prevalence of other pregnant complications(From date of participant inclusion until the date of termination of pregnancy, assessed up to 8 months)
- prevalence of thyroid disease in neonates(From date of birth to 4 weeks after birth)
研究者
Rongrong Li
Nutrition physician
Peking Union Medical College Hospital