Serum Thyroglobulin as a Marker of Iodine Nutrition Status During Pregnancy in Hungarian Population
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 189
- 主要终点
- Urinary iodine concentration
研究概览
简要总结
The purpose of the investigation is to assess iodine status of pregnant women at week 16 of gestation targeting serum thyroglobulin as a biomarker of iodine deficiency. The investigators aim to assess whether pre-gestational initiation of iodine supplementation is more advantageous in comparison to supplementation start at the time of pregnancy detection.
详细描述
Mild iodine deficiency is still a public health issue in many industrialized countries, especially during pregnancy. During the last decade there was no monitoring of the iodine status in pregnancy in Hungary.
Since urinary iodine concentration (UIC) only reflects recent iodine intake and carries limited information on individual existing iodine stores, another biomarker e.g. measurement of serum thyroglobulin concentration, would be useful to gain comprehensive information. In the present study, the purpose of the investigation is to compare UIC, UIC normalized to creatinine concentration and serum thyroglobulin as biomarkers of iodine supply in pregnant women in a geographical region where previously iodine deficiency had been found.
UIC, serum thyroglobulin level and thyroid function are measured, and information about iodine supplementation and smoking before and during pregnancy are recorded.
研究设计
- 研究类型
- Observational
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •healthy pregnant women at week 16 of gestation
排除标准
- •thyroid disease
结局指标
主要结局
Urinary iodine concentration
时间窗: At subject enrollment
Measurement of urinary iodine concentration (by inductively coupled plasma mass spectrometry) normalized to urine creatinine concentration
Serum thyroglobulin concentration
时间窗: At subject enrollment
Measurement of serum thyroglobulin concentration by chemiluminescent immunoassay
次要结局
- Serum thyroid stimulating hormone concentration(At subject enrollment)
- Serum anti-thyroglobulin autoantibody concentration(At subject enrollment)
- Serum free triiodothyronine concentration(At subject enrollment)
- Serum free thyroxine concentration(At subject enrollment)
研究者
Endre V Nagy
Professor
University of Debrecen