What is the post operative opioid-reducing effect of the beta-receptor-agonist esmolol when administered during laparoscopic gastric by-pass surgery? Comparison between standard anesthesia and anesthesia when remifentanil is replaced with esmolol.

niveritetssjukhuset Örebro0 个研究点开始时间: 2014年9月9日最近更新: 2015年10月19日

适应症

试验速览

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•1. 18-65 year of age, male or female planned for laparoscopic gastric by-pass surgery
•2. Signed and dated informed consent
•3. The volunteer is willing and thought to be able to follow the study protocol
•4. BMI > 35kg/m2
•Are the trial subjects under 18? no
•Number of subjects for this age range:
•F.1.2 Adults (18-64 years) yes
•F.1.2.1 Number of subjects for this age range 20
•F.1.3 Elderly (>=65 years) no
•F.1.3.1 Number of subjects for this age range

•1. Severe cardiovascular disease or cardiovascular disease with ongoing treament with beta- and/or alfa-receptor antagonist and/or calcium channel inhibitor
•2.Ongoing treatment with opioids
•3. ECG with atrio-ventricular block II-III or other severe form of conduction disturbance (e.g. long QT-syndrome)
•4. Allergy or sensitivity to remifentanil, fentanyl like opioids, esmolol or other compounds
•5. Pregnancy or breast feeding.
•6. Participation in a ongoing drug study or, during the last year participated in a drug study where opioid is included or participation in a pharmacological study of any kind the last 30 days or where the monitoring is not yet completed

发起方

niveritetssjukhuset Örebro