DRKS00006061
Recruiting
未知
Cardiac Magnetic Resonance Spectroscopic Correlates of Cardiac Sympathetic Denervation in Parkinson’s disease: A Comparison with MSA-P and Healthy Controls
Abteilung für Neurobiologie, Department für Neurologie, Medizinische Universität Innsbruck0 sites60 target enrollmentMay 30, 2014
Overview
- Phase
- 未知
- Intervention
- Not specified
- Conditions
- G20
- Sponsor
- Abteilung für Neurobiologie, Department für Neurologie, Medizinische Universität Innsbruck
- Enrollment
- 60
- Status
- Recruiting
- Last Updated
- last year
Overview
Brief Summary
No summary available.
Investigators
Eligibility Criteria
Inclusion Criteria
- •PD Patients:
- •Clinical diagnosis of PD according to the UK Parkinson’s Disease Society Brain Bank Diagnostic Criteria (Hughes, Ben\-Shlomo et al. 1992\)
- •Current age between 30 – 90 years
- •The subject must be able to give written informed consent (full contractual capability)
- •The subject must be willing to participate in all study related activities and visits
- •MSA Patients:
- •Clinical diagnosis of probable MSA\-P according to the revised Gilman criteria (Gilman, Wenning et al. 2008\)
- •Current age between 30 – 90 years
- •The subject must be able to give written informed consent (full contractual capability)
- •The subject must be willing to participate in all study related activities and visits
Exclusion Criteria
- •History of other major neurological or psychiatric disorders or conditions
- •History of coronary heart disease, ischemic and non\-ischemic cardiomyopathy
- •Heart failure determined by echocardiography (ejection fraction below reference range)
- •Cardiac denervation unrelated to parkinsonism (e.g. diabetic neuropathy or heart transplantation as determined by history or laboratory findings \[i.e. HbA1c])
- •Known or suspected pregnancy or breastfeeding
- •Presence of contraindication to MRI (e.g. implants)
- •Dependence on any drug that intereferes with MIBG
Outcomes
Primary Outcomes
Not specified
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