DRKS00006061招募中未知

Cardiac Magnetic Resonance Spectroscopic Correlates of Cardiac Sympathetic Denervation in Parkinson’s disease: A Comparison with MSA-P and Healthy Controls

Abteilung für Neurobiologie, Department für Neurologie, Medizinische Universität Innsbruck0 个研究点目标入组 60 人开始时间: 2014年5月30日最近更新: 2024年8月19日

适应症

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•PD Patients:
•Clinical diagnosis of PD according to the UK Parkinson’s Disease Society Brain Bank Diagnostic Criteria (Hughes, Ben-Shlomo et al. 1992)
•Current age between 30 – 90 years
•The subject must be able to give written informed consent (full contractual capability)
•The subject must be willing to participate in all study related activities and visits
•MSA Patients:
•Clinical diagnosis of probable MSA-P according to the revised Gilman criteria (Gilman, Wenning et al. 2008)
•Current age between 30 – 90 years
•The subject must be able to give written informed consent (full contractual capability)
•The subject must be willing to participate in all study related activities and visits
•Healthy volunteers:
•Current age between 30 – 90 years
•The subject must be able to give written informed consent (full contractual capability)
•The subject must be willing to participate in all study related activities and visits

•History of other major neurological or psychiatric disorders or conditions
•History of coronary heart disease, ischemic and non-ischemic cardiomyopathy
•Heart failure determined by echocardiography (ejection fraction below reference range)
•Cardiac denervation unrelated to parkinsonism (e.g. diabetic neuropathy or heart transplantation as determined by history or laboratory findings [i.e. HbA1c])
•Known or suspected pregnancy or breastfeeding
•Presence of contraindication to MRI (e.g. implants)
•Dependence on any drug that intereferes with MIBG

发起方

Abteilung für Neurobiologie, Department für Neurologie, Medizinische Universität Innsbruck