Diagnostic value of cardiac magnetic resonance imaging vs coronary angiography as primary diagnostic strategy in heart failure with reduced ejection fraction – the randomized CMR-first/CATH-first study

German Cardiac Society0 个研究点目标入组 229 人开始时间: 2024年8月22日最近更新: 2024年9月2日

适应症

试验速览

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•1. Age =18 years
•2. Physical and mental ability to give informed consent
•3. Written informed consent for study participation
•4. Indication for coronary angiography and signed copies of patient information forms for coronary angiography and CMR
•5. Heart failure with reduced ejection fraction and a left ventricular ejection fraction =40% in echocardiography (or comparable imaging modality) within the preceding 3 months
•6. Cause of heart failure not yet determined
•7. Hospital admission for coronary angiography for further evaluation of heart failure origin or in case of primary in-hospital diagnosis of HFrEF, clinical indication for coronary angiography after best possible cardiac recompensation

•1. Pregnancy
•2. End-stage renal disease (glomerular filtration rate <30 ml/min/m² (MDRD) and/or dialysis-dependency)
•3. Acute coronary syndrome
•4. History of coronary artery disease or myocardial infarction
•5. Acutely decompensated heart failure or heart failure stage NYHA IV
•6. Valvular stenosis (any) =grade II
•7. Standard exclusion criteria for cardiac MRI (e.g., incompatible metallic implants or devices, known, claustrophobia, allergy against gadolinium-based contrast agents, bodily dimensions incompatible with scanner)

发起方

German Cardiac Society