Cardiac magnetic resonance imaging and Echocardiogram to investigate myocardial structural and functional changes in patients undergoing irradiation for left sided breast cancer with or without Deep Inspiration Breath Hold

Not Applicable

Recruiting

• Conditions: Breast cancer; Cardiovascular disease; Cancer - Breast; Cardiovascular - Other cardiovascular diseases

• Registration Number: ACTRN12618001303235
• Lead Sponsor: Princess Alexandra Hospital

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2018-08-02
• Last Update Posted: 7 December 2020

Recruitment & Eligibility

• Status: Recruiting
• Sex: Female
• Target Recruitment: 40

Inclusion Criteria

1.Patients with histologically proven left sided breast cancer requiring radiation therapy to either the left breast, left chest wall and or regional nodal areas (supraclavicular fossa and or internal mammary chain and or axilla)

2.Patients who are able to comply with DIBH

3.Patients who are unable to comply with DIBH

4.No contraindications to MRI

5.No contraindication to Gadolinium contrast (normal renal function)

6.Able to provide written informed consent

7.Available for follow -up

Exclusion Criteria

1.Contraindications to MRI including but not limited to: electrically, magnetically or mechanically activated implants, vascular clips, metallic plates, cardiac stents or metal fragments in your body

2.Renal function (eGFR < 60mL/min/1.73m2)

3.Ccontraindication for Gadolinium contrast including but not limited to allergy to gadolinium

2.4.Claustrophobia

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
The incidence of myocardial structural changes (interstitial fibrosis) as measured by cardiac MRI T1 mapping sequences[6 months post radiation therapy for left sided breast cancer];The incidence of myocardial functional changes as measured by global longitudinal strain on echocardiogram[Six months post radiation therapy for left sided breast cancer]

Secondary Outcome Measures

Name	Time	Method
The incidence of myocardial structural changes (interstitial fibrosis) as measured by cardiac MRI T1 mapping sequences in patients undergoing DIBH compared with those not undergoing DIBH during radiation therapy for left sided breast cancer.<br><br>[Six months post completion of radiation therapy for left sided breast cancer];The incidence of myocardial functional changes as measured by global longitudinal strain on echocardiogram in patients undergoing DIBH compared with those patients not undergoing DIBH during radiation therapy for left sided breast cancer[Six months post completion of radiation therapy for left sided breast cancer]