Cardiovascular Magnetic resonance imaging and Echocardiography in Rheumatoid Arthritis - Patterns of cardiovascular dysfunction in patients with rheumatoid arthritis.

• Conditions: - cardiovascular disease - rheumatoid arthritis - cardiac magnetic resonance imaging - echocardiography - cardiovasculaire ziekte - reumatoide artritis - cardiale MRI - echocardiografie

• Registration Number: NL-OMON21327
• Lead Sponsor: Medisch Spectrum Twente, Enschede, The NetherlandsDepartment of Cardiology and Department of Rheumatology

Brief Summary

/A

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 28 February 2024

Recruitment & Eligibility

• Status: Pending
• Sex: Not specified
• Target Recruitment: 80

Inclusion Criteria

Participants in this study will be selected from a large database of RA patients at the rheumatology department. Three groups of patients with rheumafactor positive and anti-CCP positive rheumatoid arthritis will be selected. The first group consists of 30 patients with new onset rheumatoid arthritis (early RA group, < 1 year disease duration). The second group consists of 20 patients with intermediate duration of rheumatoid arthritis (intermediate RA, 5-10 years disease duration, erosive disease, expert based stable low disease activity > 6 months). The third group consists of 30 patients with longstanding rheumatoid arthritis (longstanding RA, > 15 years disease duration, erosive disease, expert based stable low disease activity > 6 months). The age of the study population is 18-75 year

Exclusion Criteria

previous CV disease, current smoking, age < 18 or > 75 years, pregnancy, history of kidney dysfunction (GFR < 60 ml/min), hypercholesterolemia/dyslipidemia (total cholesterol > 6.5 mmol/l), history of hypertension (systolic pressure > 140 mmHg, diastolic pressure > 90 mmHg) or use of antihypertensive medication, history of diabetes mellitus (fasting glucose level > 7.0 mmol/l), body mass index > 30 kg/m2, claustrophobia or other exclusion criteria for MRI such as implanted metal materials.

Study & Design

• Study Type: Observational non invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
With this pilot study we want to determine parameters that are useful for further follow-up studies in patient with RA in assessing cardiovascular risk with cardiac imaging techniques.