The influence of rehydration and the antidiuretic hormone on blood coagulation in the dehydrated patient
- Conditions
- vochthuishoudingdehydrationfluid deficiency10052547
- Registration Number
- NL-OMON38865
- Lead Sponsor
- Slotervaartziekenhuis
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Withdrawn
- Sex
- Not specified
- Target Recruitment
- 12
a. Adults * 18 years old.
b. Able to provide informed consent.
c. Confirmed infection of any cause (for 6 patients)
a. Strong suspection of an infection of any cause (for 6 patients) see definition of infection
b. Primary polydipsia and diabetes insipidus.
c. Untreated thyroid and adrenal hormone abnormalities.
d. Pregnancy or puerperium.
e. Common etiologies of the syndrome of inappropriate antidiuretic hormone (SIADH); Active malignancy, inflammatory diseases (multiple sclerosis, meningitis, systemic lupus erythematosus), acquired immuno- deficiency syndrome (AIDS), infections (tuberculosis, pneumonia, empyema) (only for those 6 patients without signs of infection), cystic fibrosis, drugs (Selective serotonine reuptake inhibitors, tricyclic antidepressants, carbamazepine, clofibrate, narcotics, antipsychotic drugs, cytotoxic drugs)
f. Potentiation of AVP antidiuretic effects: desmopressin, vasopressin, oxytocin, prostaglandin synthesis inhibitors
Study & Design
- Study Type
- Observational non invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method
- Secondary Outcome Measures
Name Time Method