Vitamin D Administration in the Nursing Home
- Conditions
- OsteoporosisVitamin D Deficiency
- Interventions
- Drug: placebo
- Registration Number
- NCT00204919
- Lead Sponsor
- University of Wisconsin, Madison
- Brief Summary
Administration of vitamin D 50,000 units once monthly will:
* Maintain serum 25-OH vitamin D above 20 ng/ml
* Reduce falls
* Increase calcaneal BMD
* Reduce bone turnover
* Be well tolerated: volunteers will not develop hypercalcemia
* Improve performance on a swallowing quality of life questionnaire
- Detailed Description
1. Research questions: We propose a prospective double-blind, randomized, placebo-controlled trial of once-monthly vitamin D oral capsules (50,000 units) in nursing-home residents.
Subjects from several Wisconsin nursing homes were randomized to receive once-monthly vitamin D oral capsules (50,000 units) or placebo. Blood levels of 25-OH D, parathyroid hormone, serum calcium, and a marker of bone turnover will be measured periodically by standard lab assays. Swallowing quality of life was measured by questionnaire. Appropriate statistical tests (paired T tests, 95% confidence intervals will be calculated with the large sample approximation for binomial variables, other).
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 96
- Male or Female
- Nursing Home Resident in Wisconsin
- Renal Failure
- Hypercalcemia
- Metastatic Cancer
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description 1 placebo - 2 Vitamin D -
- Primary Outcome Measures
Name Time Method Plasma 25-hydroxyvitamin D levels 1 year
- Secondary Outcome Measures
Name Time Method Plasma calcium one year
Trial Locations
- Locations (1)
University of Wisconsin
🇺🇸Madison, Wisconsin, United States