Effect of vitamin D supplementation on serum 25-hydroxyvitamin D levels, inflammatory biomarkers and total antioxidant capacity in different types of vitamin D receptor polymorphisms in breast cancer wome
Phase 3
- Conditions
- Breast Cancer.Malignant neoplasm of breast
- Registration Number
- IRCT2015090623924N1
- Lead Sponsor
- Vice Chancellor for Research of Ahvaz Jundishapur University of Medical Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- Female
- Target Recruitment
- 46
Inclusion Criteria
all women who were diagnosed with stage ? breast cancer; age>20 years; 23< BMI<30; not consuming any kinds of vitamin D supplements during last 3 month; not getting any medication that affect serum vitamin D status. Exclusion criteria: the presence of any underlying disease (liver, kidney and HIV); a history of chemotherapy or radiotherapy for any reason except for current cancer; treatment with Corticosteroids; pregnancy and lactation; chronic diarrhea and malabsorption; non-iranian races (foreigners).
Exclusion Criteria
Not provided
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Tumor Necrosis Factor alpha. Timepoint: At the beginning and the end of the study. Method of measurement: ELISA.;Transforming Growth Factor beta. Timepoint: At the beginning and the end of the study. Method of measurement: ELISA.;Total Antioxidant Capacity. Timepoint: At the beginning and the end of the study. Method of measurement: ELISA.;25 (OH) D. Timepoint: At the beginning and the end of the study. Method of measurement: ELISA.;Vitamin D receptor polymorphisms (FOK1? Bsml1? Taq? Apa1). Timepoint: At the beginning of the study. Method of measurement: PCR.
- Secondary Outcome Measures
Name Time Method Antropometric Measurments (height, weight and waist circumferences). Timepoint: at the baseline and after 8 weeks of intervention. Method of measurement: Height, hip and waist circumferences in cm and weight in kg by standard method.