Respiratory and Hemodynamic Changes Induced in Mechanically Ventilated Patients for COVID-19

University Hospital, Lille1 site in 1 country15 target enrollmentApril 20, 2020

ConditionsCOVID-19 ARDS Sars-CoV2

Overview

Phase: Not Applicable
Intervention: Not specified
Conditions: COVID-19
Sponsor: University Hospital, Lille
Enrollment: 15
Locations: 1
Primary Endpoint: intrapulmonary shunt ratio
Status: Completed
Last Updated: 5 years ago

Overview Investigators Eligibility Criteria Outcomes Sites Similar Trials

Overview

Brief Summary

In the present context, it seems necessary to try to describe as precisely as possible the physiological alterations due to COVID-19. From these observations, therapeutic proposals adapted to this new disease may then be developed, particularly in the symptomatic management of the critically ill patient. It therefore seems essential to rigorously study these modifications, as they have been studied in the past for ARDS.

The aim of this non-interventional study is to describe precisely the respiratory and hemodynamic changes induced by COVID-19 in mechanically ventilated patients

Registry

clinicaltrials.gov

Start Date

April 20, 2020

End Date

November 6, 2020

Last Updated

5 years ago

Study Type

Observational

Sex

All

Investigators

Sponsor

University Hospital, Lille

Responsible Party

Sponsor

Eligibility Criteria

Inclusion Criteria

•hospitalized in intensive care for a SARS-CoV2 infection
•requiring invasive ventilation,
•intubated for less than 72 hours with PaO2/FiO2 ratio \< 200 mmHg

Exclusion Criteria

•Patient mechanically ventilated for 72 hours or more
•Patient with documented respiratory co-infection
•Patient with a contraindication to pulmonary artery catheter insertion: High risk of bleeding, pre-existing high degree of atrioventricular heart block , Pace Maker
•Patient with spontaneous ventilation
•Patient with severe ARDS with static compliance of the respiratory system \< 20 mL/cmH2O
•Patient with severe ARDS with indication of prone positioning at inclusion.
•Patient with a cardiac condition that renders the measurement of pulmonary artery occlusion pressure uninterpretable as a surrogate for left ventricle end diastolic pressure (severe mitral insufficiency, severe mitral stricture, severe aortic insufficiency).
•Patient with intracardiac shunt
•Patient with ECMO
•Minors and pregnant women.

Outcomes

Primary Outcomes

intrapulmonary shunt ratio

Time Frame: during ICU stay, in the first 72 hours of mechanical ventilation initiation

Secondary Outcomes

Evolution of respiratory variables(during ICU stay, in the first 72 hours of mechanical ventilation initiation)
Evolution of hemodynamic stability variables(during ICU stay, in the first 72 hours of mechanical ventilation initiation)