investigating the effect of pomegranate extract in asthma
Phase 2
- Conditions
- Asthma.???J45.0
- Registration Number
- IRCT20200205046384N1
- Lead Sponsor
- Ahvaz University of Medical Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- All
- Target Recruitment
- 64
Inclusion Criteria
Ages 18 to 65 years
Patients with mild to moderate persistent allergic asthma, Forced Expiratory Volume in First Second(FEV1) greater than 60%
Body mass index(BMI):18.5-30
Both sexes
Exclusion Criteria
smoking
Diabetes
Pregnancy and lactation
Autoimmune diseases
Malignancies
Digestive, liver or kidney problems
Pneumonia
Other pulmonary diseases
Antioxidant usage
blood pressure-lowering drugs (Statin and ACE Inhibitors)
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Prooxidant-antioxidant balance. Timepoint: at the beginning of the study and 8 weeks after the intervention. Method of measurement: Based on blood test using calorimetry.;Forced Vital Capacity(FVC)/Forced Expiratory Volume in First Second(FEV1)? FEV1? FVC. Timepoint: at the beginning of the study and 8 weeks after the intervention. Method of measurement: Based on the result of the spirometer- Variable scale: percent.
- Secondary Outcome Measures
Name Time Method High sensitivity C-reactive protein (hsCRP). Timepoint: At the beginning of the study and 8 weeks after intervention. Method of measurement: Laboratory measurement (quantitative luminescence) - mg / dl.;Blood pressure. Timepoint: At the beginning of the study and 8 weeks after the intervention. Method of measurement: Based on the results of the Easy Life aneroid Sphygmomanometer-mmHg.;Clinical variables and general patient status. Timepoint: At the beginning of the study and 8 weeks after the intervention. Method of measurement: Based on a questionnaire filled by a specialist physician.;IL-35. Timepoint: At the beginning of the study and 8 weeks after the intervention. Method of measurement: Based on laboratory measurements-pg/ml.;Complete blood cell count and differential count. Timepoint: At the beginning of the study and 8 weeks after the intervention. Method of measurement: Based on laboratory measurement.