Assessment Of Serum And Tissue Levels Of Cold-Inducible RNA-Binding Protein In Patients With Lichen Planus
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 80
- 试验地点
- 1
- 主要终点
- Assessment of cold-inducible RNA binding protein levels in serum and tissue
研究概览
简要总结
Lichen planus (LP) is a chronic inflammatory mucocutaneous disease of unknown etiology.
Pathogenesis of LP is not completely understood, but it's considered a T-cell-mediated autoimmune disease. Cold-inducible RNA binding protein (CIRP or CIRBP) is a member of the glycine-rich RNA-binding protein family, Recent studies proved that CIRP acts as a tumor promoter through its actions on different cellular proliferation levels, Recently, the role of the damage associated molecular proteins and cytokines was highlighted in the pathogenesis of many disorders including psoriasis, alopecia areata, vitiligo, rheumatoid arthritis, other autoimmune diseases as well as several types of cancer. The aim of this study is to compare serum and tissue levels of CIRP in patients with LP and healthy controls.
详细描述
The aims of this study are:
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Assessment of serum and tissue levels of CIRP in patients with LP.
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To compare serum and tissue levels of CIRP in patients with LP and healthy controls.
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To compare CIRP levels according to LP severity. A cross-sectional study will be conducted on 40 patients with LP and 40 age and gender matched healthy controls. Diagnosis of LP will be clinically and will be confirmed by dermoscopy.
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Methods of the study:
- Evaluation of CIRP expression:
Every participant in this study will be subjected to both blood sampling and skin biopsy taking in the same session, then each sample will be processed separately and blindly at the Clinical Pathology, and Histology Departments as following:
- Blood sampling:
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 18 Years 至 60 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Patients from both sexes aged 18 - 60 years, having clinical and dermoscopic confirmed LP and did not receive any topical or systemic treatment in the last 3 months for LP.
排除标准
- •1 . Pregnancy and lactation.
- •Patients with any infections or sepsis.
- •Patients with any other dermatological diseases associated with increased CIRP levels (eg. psoriasis, vitiligo or alopecia areata).
- •Patients with systemic illness (cardiac, renal, hepatic or respiratory), malignancy, with history of connective tissue diseases or on immunosuppressive treatment.
- •Patients who received any topical or systemic treatment for LP 3 months before the study.
- •Patients with oral, nail or scalp LP.
结局指标
主要结局
Assessment of cold-inducible RNA binding protein levels in serum and tissue
时间窗: about one year
Skin biopsies and blood samples will be taken to assess CIRBP levels
次要结局
未报告次要终点
研究者
Aya Ahmed Elsayed
Aya Ahmed Elsayed
Sohag University