An examination whether intermittent reinflation during one lung ventilation in lung resection would result in a time-dependent alteration of extravascular lung water

Not Applicable

• Conditions: elective video-assisted thoracic surgery for lung tumor requiring one lung ventilation

• Registration Number: JPRN-UMIN000008759
• Lead Sponsor: Department of Anesthesiology and Critical Care, Hiroshima University Hospital

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2012-09-03
• Last Update Posted: 17 October 2023

Recruitment & Eligibility

• Status: Complete: follow-up complete
• Sex: All
• Target Recruitment: 36

Inclusion Criteria

Not provided

Exclusion Criteria

1) decompensated cardiac disease (> class II in New York Heart Association) 2) chronic pulmonary disease (vital capacity < 50% of predicted values and/or forced expiratory volume in 1 second < 50% of forced vital capacity) 3) chronic renal failure (serum creatinine > 1.5 mg/dl) 4) altered liver function (> class B in Child-Pugh) 5) preoperative treatment with immune modulator (cytostatic drugs, corticosteroids, nonsteroidal antiinflammatory drugs, vaccination, and blood products) within a month before surgery 6) pre-existing coagulation disorders 7) symptoms of an acute inflammatory process (clinically defined or abnormal data for C-reactive protein, leukocyte count, or body temperature) 8) Arteriosclerosis obliterans and/or iliac artery stenosis and/or aneurysms with or without bypass surgeries, which would be associated with an increased risk of complications following the femoral arterial cannulation for PiCCO

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
The primary outcome is set to the change of extravascular lung water with PiCCO (Pulsion Medical Systems, Munich, Germany) determined with the single indicator transpulmonary thermodilution technique at T1; baseline time after induction of anesthesia, T2; the end of the surgical procedure and before extubation, T3; just after the admission to the ICU, and T4; 12 hour after the admission to the ICU, respectively.

Secondary Outcome Measures

Name	Time	Method
Secondary outcome includes postoperative complications within 14 days and duration of postoperative hospitalization.