Effect of Pentoxifylline on Organ Dysfunction and Mortality in Severe Sepsis

Phase 4

• Conditions: Circulatory System; sepsis

• Registration Number: PACTR201912769388623

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2019-12-04
• Last Update Posted: 29 May 2023

Recruitment & Eligibility

• Status: Complete
• Sex: All
• Target Recruitment: 100

Inclusion Criteria

1-Adult patients with age =18 years.
2-Patients with severe sepsis. The diagnosis of sever sepsis was established according to the definitions of the Surviving Sepsis Campaign (SSC) (3).
3-Sepsis was due to either nosocomial pneumonia or pelvi-abdominal sepsis

Exclusion Criteria

1.Late septic shock at presentation with multiple organ failure.
2.APACHE II score on admission >25.
3.Preexisting liver cirrhosis.
4.Preexisting end stage renal disease
5.Pregnancy.
6.History of allergy or intolerance to Pentoxifylline.
7.Patient with malignancies
8.Uncontrolled hemorrhage
9.Burn
10.Previous steroid therapy
11.Death within 24 hours of ICU admission

Study & Design

• Study Type: Interventional
• Study Design: Not specified