Effects of calcitriol on the complications of hematopoietic stem cell transplantatio

Phase 2

Conditions: Condition 1: Hodgkin’s lymphoma. Condition 2: Non-Hodgkin’s lymphoma. Condition 3: Multiple myelomas.
Hodgkin lymphoma
Follicular lymphoma, Non-follicular lymphoma, Mature T/NK-cell lymphomas, Other and unspecified types of non-Hodgkin lymphoma
Multiple myeloma and malignant plasma cell neoplasms
C82, C83,

Registration Number: IRCT2015120816837N2

Lead Sponsor: Research Center of the Hematology and Oncology and Stem Cell Transplantation, Shariati Hospital, Teh

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Complete

Sex: All

Target Recruitment: 60

Inclusion Criteria

age between 16 and 65 years; cases of Hodgkin’s lymphoma, non-Hodgkin’s lymphoma, or multiple myelomas; candidates for autologous peripheral blood hematopoietic stem cell transplantation. Exclusion criteria: baseline serum calcium >10.5mg/dL; baseline serum phosphorous >4.5mg/dL;history of renal stones in the past 5 years; baseline serum creatinine >1.3mg/dL; alkaline phosphatase x4 the upper limit of normal or higher; alanine transaminase >60U/L; total bilirubin >2mg/dL; sensitivity to calcitriol; disability for oral intake.

Exclusion Criteria

Not provided

Study & Design

Study Type: interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Time to absolute neutrophil engraftment. Timepoint: Every day after transplantation up to the day of absolute neutrophil engraftment. Method of measurement: Compelete Blood Count and Differential Test.;Time to platelet engraftment. Timepoint: Every day after transplantation up to the day of platelet engraftment. Method of measurement: Complete Blood Count Test.;Time to absolute lymphocyte recovery. Timepoint: Every day after transplantation up to the day of absolute lymphocyte recovery. Method of measurement: Compelete Blood Count and Differential Test.

Secondary Outcome Measures