Importance of Meal Fat Content and Gall Bladder Emptying for Postprandial GLP-1 Secretion in Type 2 Diabetes Patients
Completed
- Conditions
- Diabetes
- Registration Number
- NCT01374594
- Lead Sponsor
- University Hospital, Gentofte, Copenhagen
- Brief Summary
PURPOSE
The goal of the present project is to unravel the importance of bile acid-induced GLP-1 secretion (via the G protein-coupled receptor TGR5) in human physiology.
In the present study the investigators examine the GLP-1 secretion in healthy subjects and in Type 2 Diabetes Mellitus (T2DM) patients. The investigators hypothesize that patients with T2DM of relatively long duration will be characterized by reduced gall bladder emptying, and, consequently, reduced intestinal TGR5 activation; resulting in attenuated postprandial GLP-1 responses (primary endpoint).
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 30
Inclusion Criteria
(Healthy)
- HbA1 < 6 %
- Normal haemoglobin levels
- Informed content
Inclusion Criteria: (T2DM)
- T2DM > 5 years
- Normal haemoglobin levels
- Informed content
Exclusion Criteria
(T2DM)
- Treatment with insulin, DPP-IV inhibitor or GLP-1 analogues
- Obesity (BMI > 30)
- Age > 70 years
- Gastrointestinal disease
- Nephropathy
- Liver disease
- Medication which cannot be on hold for 12h
- Gastrointestinal surgery
Exclusion Criteria: (Healthy)
- 1st degree relatives with diabetes
- Obesity (BMI > 30)
- Age > 70 years
- Gastrointestinal disease
- Nephropathy
- Liver disease
- Medication which cannot be on hold for 12h
- Gastrointestinal surgery
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method GLP-1 secretion Postprandial
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Gentofte University Hospital
🇩🇰Hellerup, Denmark