Bile Acid-induced GLP-secretion. A Study in Cholecystectomized Subjects
Completed
- Conditions
- Diabetes
- Registration Number
- NCT01251510
- Lead Sponsor
- University Hospital, Gentofte, Copenhagen
- Brief Summary
PURPOSE
The goal of the present project is to unravel the importance of bile acid-induced GLP-1 secretion (via the G protein-coupled receptor TGR5) in human physiology.
In the present study the investigators examine the GLP-1 secretion in healthy subjects and cholecystectomised patients. Thereby the investigators aim to show, that cholecystectomised patients have reduced bileflow after a meal, and as a consequence exhibit a diminished GLP-1 response as compared to healthy subjects.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 20
Inclusion Criteria
(Healthy)
- Normal fasting plasma glucose
- Normal glucose tolerance
- Normal haemoglobin levels
- Informed content
Inclusion Criteria: (cholecystectomy group)
- Laparoscopic cholecystectomy <6 months. Indication: Gallstones.
- Normal fasting plasma glucose
- Normal glucose tolerance
- Normal haemoglobin levels
- Informed content
Exclusion Criteria
(both groups)
- Diabetes
- Pre diabetes (impaired glucose tolerance or impaired fasting glucose)
- 1st degree relatives with diabetes
- Obesity (BMI > 30)
- Inflammatory bowels disease
- Nephropathy
- Liver disease
- Medication which cannot be on hold for 24h
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method GLP-1 secretion Postprandial
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Gentofte University Hospital
🇩🇰Hellerup, Denmark