Childhood Health Outcomes in Term, Large-for-gestational-age Infants: Effects of Lifestyle Intervention in the Postnatal First Year
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Childhood Overweight
- Sponsor
- Xinhua Hospital, Shanghai Jiao Tong University School of Medicine
- Enrollment
- 138
- Locations
- 1
- Primary Endpoint
- Rate of overweight/obesity at 7 years old
- Status
- Recruiting
- Last Updated
- 5 years ago
Overview
Brief Summary
Large-for-gestational-age (LGA) infants have a higher risk of metabolic disease later in life, and their postnatal growth in early childhood may be associated with long-term adverse outcomes. The purpose of this study is to explore whether comprehensive lifestyle intervention in the first year after birth in LGA infants will reduce the rate of overweight/obesity at childhood and improve neurodevelopmental outcomes and its possible mechanism.
Detailed Description
Term LGA infants will be randomly divided into two groups shortly after birth: intervention group and control group. Infants in intervention group will attend the follow-up clinic and motor development assessment and guidance will be provided every three months in the first year. Other lifestyle interventions include feeding guidance and healthcare education. Infants in control group will routinely attend the follow-up clinic every six months. Primary outcome is the rate of overweight/obesity at two years old and seven years old. Neurodevelopmental assessment, carotid intima-media thickness (CIMT) and blood pressure at childhood will also be evaluated. The association of the outcome of LGA infants at two years old and the biomarkers in cord blood will be investigated, which includes serum leptin, insulin, insulin-like growth factors -1 (IGF-1), blood lipid series and adiponectin.
Investigators
Eligibility Criteria
Inclusion Criteria
- •large-for-gestational-age infants
Exclusion Criteria
- •major genetic disorder
- •congenital anomalies
- •severe digestive disease
Outcomes
Primary Outcomes
Rate of overweight/obesity at 7 years old
Time Frame: at 7 years old
Weight and height will be combined to report BMI in kg/m\^2. According to the intergrowth-21st age-specific BMI standard issued in 2014, BMI ≥ 85th percentile is defined as overweight; BMI ≥ 95th percentile is defined as obesity
Rate of overweight/obesity at 2 years old
Time Frame: at 2 years old
Weight and height will be combined to report BMI in kg/m\^2. According to the intergrowth-21st age-specific BMI standard issued in 2014, BMI ≥ 85th percentile is defined as overweight; BMI ≥ 95th percentile is defined as obesity
Secondary Outcomes
- Neurodevelopmental assessment at 2 years old(at 2 years old)
- Association of BMI at 2 years old with biomarkers in cord blood(at 2 years old)
- Association of BMI at 7 years old with biomarkers in cord blood(at 7 years old)
- Carotid intima-media thickness (CIMT) at 2 years old(at 2 years old)
- Blood pressure at 7 years old(at 7 years old)
- Carotid intima-media thickness (CIMT) at 7 years old(at 7 years old)