Shedding of the endothelial surface layer in patients with aneurysmal subarachnoid hemorrhage

• Conditions: I60.9; I67.1; Subarachnoid haemorrhage, unspecified; Cerebral aneurysm, nonruptured

• Registration Number: DRKS00009724
• Lead Sponsor: Klinik für Anästhesiologie und Operative Intensivmedizin, Uniklinik Köln

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2015-12-14
• Study Completion: 2018-03-31
• Results First Posted: 2023-04-01
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Complete
• Sex: All
• Target Recruitment: 18

Inclusion Criteria

Acute subarachnoid hemorrhage due to vascular aneurysm treated on a neurosurgical intensive care unit.

Exclusion Criteria

Rejection of participation, any cancer, regular use of immune suppressing drugs, history of stroke or TIA in the last three months.

Study & Design

• Study Type: observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Time course of markers for endothelial shedding of the glycocalyx and potential modulating interacting factors in serum (heparansulfate, syndecan-1) and cerebrospinal fluid (adiponectin, leptin) during the first 14 days of hospitalization

Secondary Outcome Measures

Name	Time	Method
Influence of clinical treatment on the course of the glycocalyx-shedding.