Drugs Experience for Adolescents With Anorexia

Recruiting

• Conditions: Psychotropic Drugs; Anorexia Nervosa; Adolescent
• Interventions: Other: Semi-structured interviews with visual mediations; Other: Semi-structured interviews

• Registration Number: NCT06211517
• Lead Sponsor: Assistance Publique - Hôpitaux de Paris

Brief Summary

The purpose of this study is to access to the experiences of adolescents, their parents and healthcare professionals regarding psychotropic drugs in anorexia nervosa.

No preconceived ideas (according to qualitative methods) but a question: what are the participants' perceptions and experiences of psychotropic drugs in anorexia nervosa? In an adolescent medicine department.

Detailed Description

Psychotropic prescription is common to adolescents suffering from anorexia nervosa. A first qualitative study (E3A Protocol "Experience of adolescents with anorexia nervosa toward antidepressants") looked at the experience of antidepressants among 15 adolescents suffering from anorexia nervosa. Analysis of the interviews identified two meta-themes:

1. Reactions to the proposal of antidepressant with an opposition phase (about the existence of depressive symptoms and about negative preconceptions) and need to share with family and other teenagers.

2. Reactions to antidepressant use with ambivalence and an initial perception of coercion, and effects of antidepressants (psychological effects, effects on the body and on anorexia nervosa and effects perceived through the eyes of others).

Nine adolescents (out of 15) were also taking an atypical antipsychotic (APA) often prescribed in case of anorexia nervosa resistance.

The need to share with family about the proposal of antidepressant and the effects perceived through the eyes of others (including parent's eyes) lead us to take an interest in parents perceptions.

Two decisive periods were identified: What do healthcare professionals think about psychotropic treatments for anorexia nervosa in adolescence? How do they propose treatment?

Interviewing teenagers, their parents as well as healthcare professionals, will enable to access to the complexity of representations and experiences of these psychotropic drugs in anorexia nervosa.

Study Timeline

• Study First Submitted: 2024-01-08
• Study First Submitted QC: 2024-01-08
• Study First Posted: 2024-01-18
• Study Start: 2024-05-20
• Status Verified: 2024-06
• Last Update Submitted: 2024-06-20
• Last Update Posted: 2024-06-21
• Primary Completion: 2027-05
• Study Completion: 2027-12

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 90

Inclusion Criteria

Adolescents :

• Aged 12 to 25 years
• Suffering from anorexia nervosa (restrictive or mixed) according to DSM-5 (Diagnostic and Statistical Manual) criteria
• Received psychotropic drugs (antidepressant treatment and/or APA) during their care, either ongoing or discontinued before this study started

Parents of adolescents suffering from anorexia nervosa for whom a psychotropic drug has been prescribed and whose adolescents meet inclusion criteria

Healthcare Professionals working with adolescents suffering from eating disorders

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Exclusion Criteria

Adolescents :

• Atypical eating disorder that does not meet the DSM-5 criteria for restrictive or mixed anorexia nervosa
• BMI<15
• Prescription of an antidepressant other than an SSRI (Selective Serotonin Reuptake Inhibitor)
• Prescription of an APA for the indication of psychotic symptoms

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Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Parents	Semi-structured interviews with visual mediations	Parents whose adolescents suffer from anorexia nervosa
Healthcare professionals	Semi-structured interviews	Healthcare professionals in charge of adolescents suffering from anorexia nervosa
Adolescents	Semi-structured interviews with visual mediations	Adolescents suffering from anorexia nervosa 12 to 25 years

Primary Outcome Measures

Name	Time	Method
Semi-structured interview	Day of inclusion	Themes describing adolescent experiences regarding psychotropic drugs in anorexia nervosa - Emergence of themes describing participants' experience from analysis of qualitative interviews (with Interpretative Phenomenology Analysis methodology)

Secondary Outcome Measures

Name	Time	Method
Semi-structured interview	Day of inclusion	Themes describing healthcare professionals experiences regarding psychotropic drugs for adolescents suffering from anorexia nervosa - Emergence of themes describing participants' experience from analysis of qualitative interviews (with Interpretative Phenomenology Analysis methodology)

Trial Locations

Locations (1)

Maison de Solenn Maison des Adolescents, Cochin Hospital; 🇫🇷 Paris, IDF, France