Learning and Executive Function Disorders in Children and Psychosis Risk at Adult-age

Completed

• Conditions: Schizophrenia; Executive Function Disorders; Learning Disorders
• Interventions: Diagnostic Test: Standardised semi-structured talk; Diagnostic Test: Autistic spectre disorder screening; Diagnostic Test: Anxiety measuring

• Registration Number: NCT04280367
• Lead Sponsor: Assistance Publique - Hôpitaux de Paris

Brief Summary

The primary objective of the study aims to study transition toward schizophrenia in patients with learning disorders, and to compare the risk between patients with specific learning disorders, and patients with complexed learning disorders (by two types: patients with other neuro-developmental disorders including executive function disorders, and patients with anxiety).

Detailed Description

As secondary objectives, the study aims to:

* argue the clinical predicted markers (neuropsychological) transition toward psychosis.

* test the feasibility and the acceptability of a early diagnosis for a potential applicable guidance for different referent centers of learning in French territory.

* have a better classification of patients with learning disorders in order to target a prospective primary prevention of risk of psychosis via the questionnaires (AQ of Baron-Cohen: Autism-spectrum quotient auto-questionnaire; Inventory of Beck Anxiety Inventory, auto-questionnaire for panic disorder and general anxiety; Liebowitz Social Anxiety Scale).

* improve identification of the early signs and the early emerging psychological diseases intervention management (schizophrenia).

* Psychic disability: prevent and reduce non-seeking care and accompaniment situations, and risk of rupture of care.

* permitting better care of psychosocial rehabilitation with cognitive evaluation.

This study will be conducted in Centre de référence des troubles du langage et des apprentissages, Hôpital Raymond Poincaré, APHP, in France.

Study Timeline

• Study Start: 2020-01-28
• Study First Submitted: 2020-02-20
• Study First Submitted QC: 2020-02-20
• Study First Posted: 2020-02-21
• Primary Completion: 2020-05-29
• Study Completion: 2020-05-29
• Status Verified: 2023-08
• Last Update Submitted: 2023-08-21
• Last Update Posted: 2023-08-22

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 20

Inclusion Criteria

• Patients born between 1990 and 2005, have been cared by Dr Schlumberger in 2014 in the center of language and learning disorders at Raymond Poincaré hospital;
• With severe learning disorders: deficiency in school work, need at least one medical appointment and long-term rehabilitation in the center of language and learning disorders at Raymond Poincaré hospital;
• Affiliated to a social protection schema;
• Written informed consent signed.

Exclusion Criteria

• Absence of learning disorder;
• Intellectual deficiency;
• Epilepsia;
• Patients who will performed follow-up at Chartres city;
• Patients under guardianship or curatorship;
• Foreign patients under AME schema, a medical help from the state in France.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
neuro-developmental complexed group	Autistic spectre disorder screening	Group of neuro-developmental complexe of learning
Comparator group	Standardised semi-structured talk	Specific learning disorders group
Comparator group	Anxiety measuring	Specific learning disorders group
Complexed with anxiety	Anxiety measuring	Disorders in learning with anxiety
neuro-developmental complexed group	Standardised semi-structured talk	Group of neuro-developmental complexe of learning
Comparator group	Autistic spectre disorder screening	Specific learning disorders group
neuro-developmental complexed group	Anxiety measuring	Group of neuro-developmental complexe of learning
Complexed with anxiety	Standardised semi-structured talk	Disorders in learning with anxiety
Complexed with anxiety	Autistic spectre disorder screening	Disorders in learning with anxiety

Primary Outcome Measures

Name	Time	Method
Semi-structured interview	At baseline	Assessement with Comprehensive Assessment of At-Risk Mental States (CAARMS) during 6 to 90 minutes at the center of Raymond Poincaré hospital.; The unique collection during the interview, quotation of each patient will be given from the assessement.; There will be 4 groups by the results: CAARMS negative subjects, vulnerable subjects, attenuated psychosis subjects and subjects with brief and limited intermittent psychotic syndrome. The further statistic comparison will be done between the 3 last groups classified with results of CAARMS.

Secondary Outcome Measures

Name	Time	Method
Autistic screening	At baseline	Autism-spectrum quotient (AQ) auto-questionnaire will be used to evaluate difficulty in social interaction.
Anxiety measuring	At baseline	An inventory for measuring clinical anxiety: Beck Anxiety Inventory
Social interaction difficulty evaluation	At baseline	Liebowitz Social Anxiety Scale as questionnaire

Trial Locations

Locations (1)

Centre de référence des troubles du langage et des apprentissages, Hôpital Raymond Poincaré; 🇫🇷 Garches, France