Nano Fat Injection With or Without Fractional Carbon Dioxide Laser in Acne Scars

Not Applicable

Not yet recruiting

• Conditions: Acne Scars - Atrophic
• Interventions: Procedure: Fat grafting

• Registration Number: NCT05985265
• Lead Sponsor: Assiut University

Brief Summary

Assessment of nano fat grafting combined with carbon dioxide laser resurfacing versus nano fat grafting alone in treating facial atrophic acne scars

Detailed Description

Acne scars is a world wide problem .though lots of treatment exists still mo gold standard for treatment of acne scars in this study.

Assessment of nano fat grafting combined with carbon dioxide laser resurfacing versus nano fat grafting alone in treating facial atrophic acne scars

Study Timeline

• Study First Submitted: 2022-11-15
• Status Verified: 2023-08
• Study First Submitted QC: 2023-08-08
• Last Update Submitted: 2023-08-08
• Study First Posted: 2023-08-14
• Last Update Posted: 2023-08-14
• Study Start: 2023-09-01
• Primary Completion: 2024-04-29
• Study Completion: 2024-05-29

Recruitment & Eligibility

• Status: NOT_YET_RECRUITING
• Sex: All
• Target Recruitment: 50

Inclusion Criteria

• patients older than 18 years who attend the Outpatient Clinics of Dermatology and Plastic Surgery Departments, Assiut University Hospital, with moderate to severe atrophic facial acne scars on both cheeks, as assessed using the Goodman and Baron Qualitative scar grading system (12), will be enrolled in the study.

Exclusion Criteria

• include: pregnancy or lactation; active acne, history of deep chemical peeling or filler injection in the previous 6 months, history of keloid or hypertrophic scar formation; use of isotretinoin in the previous 6 months; active infection in the treatment area; bleeding tendencies; history of herpes simplex or herpes zoster infection on the face; and patients with unrealistic expectations.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
Nano fat grafting and fractional carbon dioxide laser resurfacing	Fat grafting	treating of atrophic acne scars with nano fat and fractional carbon dioxide laser

Primary Outcome Measures

Name	Time	Method
Clinical assessment of acne scar severity	up to 24 weeks	as assessed using the Goodman and Baron Qualitative scar grading system before and after treatment on both sides of face, to determine the number of patients achieving two grades improvement vs one grade or no improvement

Secondary Outcome Measures

Name	Time	Method
percent of reduction in scar count	up to 24 weeks	count of the total and different types of acne scars was performed, before and after treatment on both sides of the face, and the percent of reduction was calculated
Physician global assessment	up to 24 weeks	two blinded observers will compare the before and after photographs separately on each facial side and will evaluate the improvement on a quartile grading scale as: poor,\<25% improvement; fair, 25%-50% improvement; good, 51%-75% improvement; and excellent, \>75% improvement.
Adverse events	1 year	erythema, edema, crusting, pigmentary changes, ecchymosis, and scarring, will be recorded
Patient satisfaction	1 year	Patients will rate their overall satisfaction on a quartile grading system: 0, unsatisfied; 1, slightly satisfied; 2, satisfied; and 3, very satisfied

Trial Locations

Locations (1)

Faculty of Medicine, Assiut University; 🇪🇬 Assiut, Egypt