Corneal Epithelial Remodeling and Corneal Asphericity after Transepithelial Photorefractive Keratectomy for Myopia and Myopic Astigmatism

This prospective observational study will be conducted at Sankara Eye Hospital, Coimbatore, on 45 patients with myopia or myopic astigmatism undergoing transepithelial photorefractive keratectomy (Trans-PRK) using the Schwind Amaris 1050 excimer laser. The corneal epithelium has a non-uniform thickness and undergoes remodeling after refractive surgery, which can influence corneal curvature, asphericity (Q-value), and visual outcomes. Patients will be followed up at 1 month, 3 months, and 6 months. At each visit, visual acuity, corneal epithelial thickness mapping at central (2 mm), paracentral (2–4 mm), and peripheral (4–6 mm) zones using Anterion, and Q-value analysis will be performed. The primary objective is to evaluate epithelial remodeling and corneal asphericity after Trans-PRK. Secondary objectives include correlation of remodeling with visual acuity and comparison of epithelial remodeling patterns between spherical myopia and myopic astigmatism. The study is expected to provide insights into epithelial healing patterns, their impact on optical quality, and guidance for improving refractive surgery planning and outcomes.