Influence of Breastfeeding on Gut Health in Children
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Gut Health
- Sponsor
- University Hospital, Lille
- Enrollment
- 500
- Locations
- 1
- Primary Endpoint
- Correlation between exclusive breastfeeding and gut health based on the non-invasive measurement of fecal secretory immunoglobulin A (sIgA)
- Status
- Recruiting
- Last Updated
- last year
Overview
Brief Summary
The aim of the study is to evaluate the impact of early nutrition on gut health in children. A prospective cohort of newborns will be recruited at birth and followed up to 4 years of age. Information on parent's nutritional habits and life style, breastfeeding duration and child's complementary feeding, will be collected. Cord blood cells and stools will be collected at birth, 6 months, 2 years and 4 years of age for implementing a biological collection. Gut health will be evaluated in children during the first four years of life based on fecal secretory immunoglobulin A (SIgA) and presence of digestive symptoms. Precise data on breastfeeding practices and their short- and medium-term effects on the health of the child, in particular and in an innovative way on gut health, will be obtained.
Investigators
Eligibility Criteria
Inclusion Criteria
- •For the mother:
- •Pregnant woman (\>18 years old) followed at the Lille University Jeanne de Flandres Maternity
- •Woman who can speak, read and write in French
- •Single pregnancy
- •Informed consent
- •Living in the Lille area
- •For the father:
- •Men \>18 years old
- •Informed consent
Exclusion Criteria
- •For the mother:
- •Impossibility to participate to the study follow-up
- •Woman under guardianship or curatorship
- •Woman involved in another study inconsistent with biological samples collection
- •For the child after birth:
- •Prematurity \<37 weeks
- •Impossibility to participate to the study follow-up
- •Child under judicial protection measure
- •Child involved in another study inconsistent with biological samples collection
Outcomes
Primary Outcomes
Correlation between exclusive breastfeeding and gut health based on the non-invasive measurement of fecal secretory immunoglobulin A (sIgA)
Time Frame: AT 4 years
Secondary Outcomes
- Correlation between gut health and the duration of exclusive breastfeeding(A 1 month, 1-2 months, 2-4 months, 4-6 months, 6 months)
- Correlation between sIgA and child growth and gastro-intestinal disorders(At 6 months, 2 years and 4 years)
- Correlation between the mother's feeding habits during pregnancy and the child's gut health during the first 4 years of life(At 6 months, 2 years and 4 years)