Influence of Breastfeeding on Gut Health in Children
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 500
- 试验地点
- 1
- 主要终点
- Correlation between exclusive breastfeeding and gut health based on the non-invasive measurement of fecal secretory immunoglobulin A (sIgA)
研究概览
简要总结
The aim of the study is to evaluate the impact of early nutrition on gut health in children. A prospective cohort of newborns will be recruited at birth and followed up to 4 years of age. Information on parent's nutritional habits and life style, breastfeeding duration and child's complementary feeding, will be collected. Cord blood cells and stools will be collected at birth, 6 months, 2 years and 4 years of age for implementing a biological collection. Gut health will be evaluated in children during the first four years of life based on fecal secretory immunoglobulin A (SIgA) and presence of digestive symptoms. Precise data on breastfeeding practices and their short- and medium-term effects on the health of the child, in particular and in an innovative way on gut health, will be obtained.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •For the mother:
- •Pregnant woman (>18 years old) followed at the Lille University Jeanne de Flandres Maternity
- •Woman who can speak, read and write in French
- •Single pregnancy
- •Informed consent
- •Living in the Lille area
- •For the father:
- •Men >18 years old
- •Informed consent
排除标准
- •For the mother:
- •Impossibility to participate to the study follow-up
- •Woman under guardianship or curatorship
- •Woman involved in another study inconsistent with biological samples collection
- •For the child after birth:
- •Prematurity <37 weeks
- •Impossibility to participate to the study follow-up
- •Child under judicial protection measure
- •Child involved in another study inconsistent with biological samples collection
结局指标
主要结局
Correlation between exclusive breastfeeding and gut health based on the non-invasive measurement of fecal secretory immunoglobulin A (sIgA)
时间窗: AT 4 years
次要结局
- Correlation between gut health and the duration of exclusive breastfeeding(A 1 month, 1-2 months, 2-4 months, 4-6 months, 6 months)
- Correlation between sIgA and child growth and gastro-intestinal disorders(At 6 months, 2 years and 4 years)
- Correlation between the mother's feeding habits during pregnancy and the child's gut health during the first 4 years of life(At 6 months, 2 years and 4 years)