Effects of Probiotics on the Gut Microbiome of Infants Treated With Antibiotics
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Gastrointestinal Microbiome
- Sponsor
- Shanghai 10th People's Hospital
- Enrollment
- 30
- Locations
- 1
- Primary Endpoint
- change from birth,7 days,14 days(or 21 days) on gut mcrobiome at 42 days
- Last Updated
- 8 years ago
Overview
Brief Summary
The purpose of this study is to evaluate the effect of probiotics on the gut microbiome of infants treated with antibiotics.
Detailed Description
This study aims to examin the impact of probiotics under 2 separate conditions, probiotics concurrent administration with antibiotic and probiotics administration during the recovery phase.Birth,7 days,14 days(or 21 days) and 42 days data will be collected and put into analysis to provide somes suggestions on the probiotics use in the clinical for the infants treated with antibiotics.
Investigators
Huanlong Qin
Director
Shanghai 10th People's Hospital
Eligibility Criteria
Inclusion Criteria
- •Newborns with infectious diseases treated with antibiotic
Exclusion Criteria
- •Gestational weeks \<37
- •Birth weight \<2500g or ≥4000g
- •History of asphyxia anoxia at birth
- •With congenital metabolic diseases or hereditary diseases
- •With gastrointestinal diseases
Outcomes
Primary Outcomes
change from birth,7 days,14 days(or 21 days) on gut mcrobiome at 42 days
Time Frame: 42 days
change of the gut mcrobiome will be calculated at 42 days in comparison with birth,7 days,14 days(or 21 days)
Secondary Outcomes
- change from birth on gut mcrobiome at 7 days(7 days)
- change from birth and 7 days on gut mcrobiome at 14 days(or 21 days)(14 days（or 21days）)