The effect of Theobromine supplementation on anthropometric indices, glycemic indices, cardiovascular risk factors, and genes expression of PPARa and Sirt1 in subjects with metabolic syndrome.
- Conditions
- Metabolic syndrome.
- Registration Number
- IRCT20091114002709N59
- Lead Sponsor
- Iran University of Medical Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- All
- Target Recruitment
- 80
Overweight or obese (25 =BMI= 35 kg/m^2) men and women aged 40 to 55 years .
Having metabolic syndrome according to IDF definition ( Waist circumference greater than 94 cm for men and 80 cm for women, Triglyceride = 150mg/dl, HDL-c = 40mg/dl for men and HDL-c = 50mg/dl for women or medication, Systolic blood pressure = 130mmHg and DBP= 85 mmHg or medication, Fasting blood sugar= 100mg/dl or medication)
Tendency to participate in the study
Smoking
Subjects with diabetes, cancer, hepatitis, cardiovascular diseases, hematological disorders, Neurological disorders, renal disorders, gastrointestinal and thyroid disorders
Insulin therapy, use hypoglycemic and weight reduction medication, vasodilators, hormone therapy, corticosteroids, non steroid anti inflammatory drugs, antihistamines, Selective serotonin reuptake inhibitors, anti gout and psychotics medication.
Use of any vitamin and mineral supplement, antioxidants and omega3.
Pregnancy, lactation and adherence to a specific diet
People treated with statins and antihypertensive drugs will only be included in the study if they are treated for more than 3 months for statins and more than 6 months for high blood pressure.
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method
- Secondary Outcome Measures
Name Time Method