Regenerative Potential of Advanced Platelet Rich Fibrin (A-PRF) and Bioactive Glass (Perioglas®) Bone Graft in the Treatment of Intrabony Defects; A Comparative Clinico Radiographic Study.
Overview
- Phase
- Phase 4
- Intervention
- open flap debridement and filled with A-PRF ( Advanced platelet rich fibrin)
- Conditions
- Chronic Periodontitis
- Sponsor
- Maharishi Markendeswar University (Deemed to be University)
- Enrollment
- 48
- Locations
- 1
- Primary Endpoint
- probing depth
- Status
- Completed
- Last Updated
- 3 years ago
Overview
Brief Summary
The aim of this study is to evaluate and compare the regenerative potential of Advanced Platelet Rich Fibrin (A-PRF) and Bioactive Glass (Perioglas®) bone graft in the treatment of intrabony defects in chronic periodontitis patients.
Detailed Description
45 sites with vertical intrabony alveolar defects will be selected. These defect sites will be allocated randomly into 3 groups as Group I, Group II and Group III. * Group I will be treated with open flap debridement and filled with A-PRF * Group II will be treated with open flap debridement and filled with Bioactive glass (Perioglas®) * Group III will be treated with open flap debridement and filled Bioactive glass (Perioglas®) and A-PRF.
Investigators
DR SURINDER SACHDEVA
PROFESSOR
Maharishi Markendeswar University (Deemed to be University)
Eligibility Criteria
Inclusion Criteria
- •Age: 25 to 55 years.
- •Gender: Both males and females will be included in the study.
- •Co-operative and motivated patients committed to oral hygiene.
- •Patients exhibiting intrabony defects.
Exclusion Criteria
- •Patients with contraindication to periodontal surgery \& local anesthesia.
- •Any systemic disease affecting the bone density and outcome of periodontal therapy.
- •Smokers, alcoholics, and patients with other adverse habits.
- •Pregnant, nursing and menopausal women.
- •Any known allergy/ hypersensitivity to any product used in this study.
- •Patients on long-term systemic therapy (antibiotics, anti-inflammatory bisphosphonates, hormonal replacement therapy and any other), taking any drug known to have periodontal implications that may interfere with wound healing.
- •Patients taking any anti-platelet and anticoagulant medication.
- •Patients who have undergone periodontal treatment within a period of past 1 year.
Arms & Interventions
open flap debridement and filled with A-PRF
After phase 1 therapy, surgical procedure would be carried out in the selected patients under aseptic conditions. Full thickness mucoperiosteal Kirkland flap would be raised on both buccal and lingual sides using periosteal elevator. Pocket lining epithelium would be removed and a thorough debridement and root planing would be done in the intrabony defect by using Gracey curettes and universal curettes. After placement of A-PRF in bony defect site the mucoperiosteal flaps would be sutured for complete soft tissue closure.
Intervention: open flap debridement and filled with A-PRF ( Advanced platelet rich fibrin)
open flap debridement and filled with Bioactive glass (Perioglas®)
After phase 1 therapy, surgical procedure would be carried out in the selected patients under aseptic conditions. Full thickness mucoperiosteal Kirkland flap would be raised on both buccal and lingual sides using periosteal elevator. Pocket lining epithelium would be removed and a thorough debridement and root planing would be done in the intrabony defect by using Gracey curettes and universal curettes. After placement of Bioactive glass (Perioglas®) in bony defect site the mucoperiosteal flaps would be sutured for complete soft tissue closure.
Intervention: open flap debridement and filled with Bioactive glass (Perioglas®)
with open flap debridement and filled Bioactive glass (Perioglas®) and A-PRF.
After phase 1 therapy, surgical procedure would be carried out in the selected patients under aseptic conditions. Full thickness mucoperiosteal Kirkland flap would be raised on both buccal and lingual sides using periosteal elevator. Pocket lining epithelium would be removed and a thorough debridement and root planing would be done in the intrabony defect by using Gracey curettes and universal curettes. After placement of Bioactive glass (Perioglas®) along with A-PRF in bony defect site the mucoperiosteal flaps would be sutured for complete soft tissue closure.
Intervention: open flap debridement and filled Bioactive glass (Perioglas®) and A-PRF
Outcomes
Primary Outcomes
probing depth
Time Frame: baseline, 3 months, 6 months
change in probing pocket depth
relative attachment level
Time Frame: baseline, 3 months, 6 months
change in attachment level
radiographic linear bone change
Time Frame: change from baseline to 6 months
radiographic linear bone change through radiographic grid
Secondary Outcomes
- Plaque index site specific(baseline, 3 months, 6 months)
- Gingival index site specific(baseline, 3 months, 6 months)