Increased renal function in an adult intensive care setting -prevalence, risk factors and impact on clinical outcomes
Not Applicable
Not yet recruiting
- Registration Number
- CTRI/2021/01/030243
- Lead Sponsor
- Kandaswamy
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Not Yet Recruiting
- Sex
- Not specified
- Target Recruitment
- 0
Inclusion Criteria
1.Age > 18 years
2.Receiving antibiotics
3.Within 24 hours of ICU admission
4.Expected ICU stay > 24hours
5.Has an indwelling urinary catheter or has the indication to insert one
Exclusion Criteria
1.AKI on admission (as defined by KDIGO guidelines if preadmission creatinine is available and as per MDRD study calculation if preadmission creatinine is not available)
2.Non-index ICU admission
3.Chronic kidney disease as defined eGFR < 60 ml /min / 1.73m2
4.Trauma/surgery involving kidneys
5.Renal replacement therapy (RRT)
6.Patients with crush injury
Study & Design
- Study Type
- Observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method To identify the prevalence of augmented renal clearance in a mixed cohort of medical, surgical and trauma patients receiving antibiotic therapy in an adult intensive care setting of a tertiary care hospital.Timepoint: within 24hrs of admission to ICU to the time of discharge from IC
- Secondary Outcome Measures
Name Time Method a)To describe the correlation between eGFR(estimated glomerular filtration rate) measured by MDRD4(modification of diet in renal disease study equation with 4 variables) formula, Cockcroft-gault equation, CKD-EPI(Chronic kidney disease epidemiology collaboration) formula with measured 24hr urinary creatinine clearance. <br/ ><br>b)To identify the risk factors associated with ARC <br/ ><br>c)Effect of ARC on clinical outcomes <br/ ><br>1. ICU length of stay (LOS) <br/ ><br>2. ICU survivalTimepoint: within 24hrs of admission to ICU to the time of discharge from IC