In critically ill patients with acute renal failure does a strategy of intensive renal replacement therapy as compared to a strategy of less-intensive renal replacement therapy decrease all-cause mortality at 60 days

S Department of Veterans Affairs Cooperative Studies Program0 个研究点目标入组 1,164 人开始时间: 2005年11月14日最近更新: 2020年1月13日

适应症

试验速览

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•1. Acute renal failure (ARF) clinically consistent with a diagnosis of acute tubular necrosis (ATN), defined as: clinical setting of acute ischemic or nephrotoxic injury; and oliguria (average urine output < 20 mL/hr) for > 24 hours or an increase in serum creatinine of at least 2.0 mg/dL (men)/1.5 mg/dL (women) over a period of no more than 4 days
•2. Plan for renal replacement therapy
•3. Receiving care in critical care unit
•4. At least one non-renal organ failure (Sequential Organ Function Assessment organ system score of at least 2) or the presence of sepsis
•5. Age of at least 18 years
•6. Informed consent

•1. Baseline chronic kidney disease (CKD) defined by serum creatinine > 2 mg/dL (men) / 1.5 mg/dL (women)
•2. Acute renal failure (ARF) due to an etiology other than acute tubular necrosis (ATN)
•3. More than 72 hours since meeting BOTH of the following: Definition of ARF as specified in the inclusion criteria and a blood urea nitrogen (BUN) > 100 mg/dL
•4. More than 1 hemodialysis treatment or more than 24 hours of continuous renal replacement therapy (CRRT)
•5. History of kidney transplantation
•6. Weight > 128.5 kg
•7. Pregnancy
•8. Prisoner
•9. Non-candidacy for renal replacement therapy (RRT)
•10. Not expected to survive 28-days due to underlying chronic medical condition
•11. Moribund sate or comfert measures only (CMO) status
•12. Participation in a concurrent interventional trial
•13. Patient refusal
•14. Physician refusal

发起方

S Department of Veterans Affairs Cooperative Studies Program