ACTRN12612000765820
Recruiting
Phase 3
In critically ill patients with acute kidney injury does continuous renal replacement therapy (CRRT) using a machine controlled citrate protocol compared to a regional heparin protcocol improve safety and extend filter life.
Dr. Matthew Brain0 sites200 target enrollmentJuly 18, 2012
Overview
- Phase
- Phase 3
- Intervention
- Not specified
- Conditions
- Acute Kidney Injury
- Sponsor
- Dr. Matthew Brain
- Enrollment
- 200
- Status
- Recruiting
- Last Updated
- 6 years ago
Overview
Brief Summary
No summary available.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Greater than 18 years old
- •Diagnosis of acute renal failure with an indication for renal replacement therapy as assessed by one or more of the following criteria:Oliguria (urine output \< 100ml in a 6hour period) unresponsive to fluid resuscitation;volume overload, not correctable by diuretics in spite of adequate blood pressure and creatinine \> 100umol.L; increase of serum creatinine \> 300 umol/L or BUN \> 25mmol/L;increase of serum potassium \> 6\.5 mmol/L due to AKI
Exclusion Criteria
- •Patient weight \< 30kg (determined by machine specification)
- •Inability to enter randomization due to a contraindication to one of the treatment arms:
- •Indication for systemic anticoagulation with heparin (therapeutic range APTT) or an equivalent therapeutic dose of low molecular weight heparin (note this does not include routine thromboprophylaxis with these agents)
- •Prior development of HIT
- •History of anaphylaxis to heparin, protamine or citrate.
- •Pregnancy, or lactation.
- •Patients on chronic renal replacement therapy prior to ICU presentation.
- •Indication for therapeutic hypothermia
- •Previous participation in the same study
- •Indication for a filter set other than the AN69 ST100 1m2 set or a specific dialysis prescription differing from the study protocol (as deemed by the treating physician)
Outcomes
Primary Outcomes
Not specified
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