The prophylactic effect of theophylline on vancomycin-induced nephrotoxicity
Phase 2
Recruiting
- Conditions
- nephrotoxicity.
- Registration Number
- IRCT20220326054351N1
- Lead Sponsor
- Sabzevar University of Medical Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- 34
Inclusion Criteria
Patients with systemic infection treated with vancomycin
Patients one month to 18 years
Complete the informed consent form
Exclusion Criteria
Patients who are discharged from the hospital before three days.
Patients with unpredictable complications.
Patients with drug side effects.
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method The percentage of people treated with vancomycin who develop microalbuminuria. Timepoint: Measurement of microalbuminuria at the beginning of the study and 72 hours after starting treatment with vancomycin. Method of measurement: Measurement of microalbuminuria in urine sample.The range is 30-300 mg per 24 hours.;The percentage of people treated with vancomycin who experience an increase in urea and creatinineCommunity Verified icon. Timepoint: Measurement of urea and creatinine at the beginning of the study and 72 hours after starting vancomycin treatment. Method of measurement: Measurement of urea and creatinine in serum samples.Depending on the patients age, urea 20-30 mg/dL and creatinine 0.4-1 mg/dL.
- Secondary Outcome Measures
Name Time Method Patient weight change. Timepoint: before treatment & after three days from the start of treatment. Method of measurement: Measuring the patient's weight in kilograms with a digital scale.