Best time to give tranexamic acid to prevent and reduce the blood loss in cesarean deliveries.
Phase 4
- Conditions
- Health Condition 1: O720- Third-stage hemorrhage
- Registration Number
- CTRI/2024/05/066737
- Lead Sponsor
- AIIMS, Bhubaneswar
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot Yet Recruiting
- Sex
- Not specified
- Target Recruitment
- 0
Inclusion Criteria
a)Women undergoing elective or emergency LSCS.
b)Gestational age = 32weeks.
Exclusion Criteria
a)History of previous thrombotic event or preexisting pro-thrombotic disease.
b)Any active or chronic cardiovascular disease except for hypertension.
c)Any chronic or active kidney disease or insufficiency.
d)Chronic or active liver disease.
e)Autoimmune disease.
f)Sickle cell disease.
g)Placenta accreta/increta/percreta.
h)Eclampsia, HELLP syndrome
i)Received antiplatelet drugs during the week before delivery.
j)Known allergy to tranexamic acid.
k)Women who develop PPH before cord clamping
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method a) To assess the reduction in blood loss, as determined by calculated estimated blood loss (cEBL), among women undergoing cesarean delivery, by comparing those who receive prophylactic tranexamic acid 10 minutes before skin incision with those who receive it after cord clamping.Timepoint: a) Pre operative hematocrit - within 1 week before surgery. <br/ ><br>b) post operative hematocrit 6hours after surgery.
- Secondary Outcome Measures
Name Time Method To find & compare the incidence of PPH defined by a calculated estimated blood loss = 1000ml in both study groups. <br/ ><br>To compare the calculated estimated blood loss in women with risk factors in both study groups. <br/ ><br>To compare the number of women requiring blood transfusions within 48hrs of surgery in both study groups. <br/ ><br>To compare the neonatal outcome in the form of APGAR score at 5min after birth in both study groups.Timepoint: Number of packed red blood cells transfused within 48hours. <br/ ><br>APGAR score at 5 min. <br/ ><br>