Colchicine in High-risk Patients With Acute Minor-to-moderate Ischemic Stroke or Transient Ischemic Attack (CHANCE-3)
- Registration Number
- NCT05439356
- Lead Sponsor
- Beijing Tiantan Hospital
- Brief Summary
This study is a multicentre, randomized, double-blind, placebo-controlled, investigator-sponsored study that aims to investigate the efficacy of colchicine in preventing recurrent stroke in the patients with acute minor-to-moderate ischemic stroke or TIA and a hsCRP level of ≥2mg/L.
- Detailed Description
This is a multicentre, randomized, double-blind, placebo-controlled trial that aims to investigate the efficacy of colchicine in preventing recurrent stroke in the patients with acute minor-to-moderate ischemic stroke or TIA and a hsCRP level of ≥2mg/L. Patients who were eligible to the inclusion criteria and ineligible to the exclusion criteria will be randomly assigned into two groups by a 1:1 ratio. Patients in one arm will receive colchicine initiated with a dose of 1mg per day on days 1 through 3, and continuing with 0.5 mg per day on days 4 through 90, and those in the other arm will receive an equivalent placebo drug. Study visits will be performed on the day of randomization, at discharge, at day 90 and at 1 year. The primary outcome was stroke (ischemic or hemorrhagic) during 90 days of follow-up in an intention-to treat analysis.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 8343
- 40 years or older than 40 years；
- Acute cerebral ischemic event due to： Acute minor-to-moderate ischemic stroke (NIHSS≤5 at the time of randomization) or TIA with moderate-to-high risk of stroke (ABCD2 score ≥ 4 at the time of randomization)；
- With a hsCRP level of ≥2mg/L at randomization;
- Can be treated with study drug within 24 hours of symptoms onset*(*Symptom onset is defined by the "last seen normal" principle)；
- Informed consent signed.
- Malformation, tumor, abscess or other major non-ischemic brain disease (e.g., multiple sclerosis) on baseline head CT or MRI.
- Isolated or pure sensory symptoms (e.g., numbness), isolated visual changes, or isolated dizziness/vertigo without evidence of acute infarction on baseline head CT or MRI.
- Iatrogenic causes (angioplasty or surgery) of stroke or TIA.
- Presumed cardiac source of embolus, such as atrial fibrillation or prosthetic cardiac valve).
- A score of ≥ 2 on the modified Rankin scale immediately before the occurrence of the index event.
- Usage of colchicine within 30 days before randomization or planning to take colchicine therapy for other indications.
- Known allergy or sensitivity or intolerance to colchicine.
- Inflammatory bowel disease (Crohn's or ulcerative colitis) or chronic diarrhea.
- Symptomatic peripheral neuropathy or pre-existing progressive neuromuscular disease or with creatine kinase (CK) level > 3 times the upper limit of normal as measured within the past 30 days and determined to be non-transient through repeat testing.
- A history of cirrhosis, chronic active hepatitis or severe hepatic disease.
- Impaired hepatic (ALT or AST > twice the upper limit of normal range) or kidney (creatinine exceeding 1.5 times of the upper limit of normal range or eGFR less than 50 ml/min) function at randomization.
- Anemia (haemoglobin <10g/dL), thrombocytopenia (platelet count <100×109/L) or leucopenia (white blood cell <3×109/L) at randomization.
- In the acute phase of respiratory tract infection, urinary tract infection, and gastro-enteritis, or currently using or planning to receive oral or intravenous anti-infective therapy for any other infection.
- Currently using or planning to begin long-term (>7 days) systemic anti-inflammatory drugs (NSAIDs except for aspirin, oral or intravenous steroid therapy) during the study.
- Planning to use moderate or strong CYP3A4 inhibitors (clarithromycin, erythromycin, telithromycin, other macrolide antibiotics, ketoconazole, itraconazole, voriconazole, ritonavir, atazanavir, indinavir, other HIV protease inhibitors, verapamil, diltiazem, quinidine, digoxin, disulfiram, etc) or P-gp inhibitors (cyclosporine) at randomization.
- Planned surgery or interventional treatment requiring cessation of the study drug during the study.
- Participating in another clinical trial with an investigational drug or device concurrently or during the last 30 days.
- Women of childbearing age who were not practicing reliable contraception and did not have a documented negative pregnancy test or severe noncardiovascular coexisting condition.
- Severe non-cardiovascular comorbidity with a life expectancy of less than 3 months.
- With a history of clinically significant drug or alcohol abuse.
- Inability to understand and/or follow research procedures due to mental, cognitive, or emotional disorders, or to be an unsuitable candidate for the study for any other considered by the investigator.
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Placebo Colchicine Group Placebo colchicine Patients in this arm will receive placebo colchicine for 90 days in addition to standard medical care Colchicine Group Colchicine Patients in this arm will receive colchicine for 90 days in addition to standard medical care
- Primary Outcome Measures
Name Time Method Any new stroke events any time within 90 days Incidence of any new ischemic or hemorrhagic stroke
- Secondary Outcome Measures
Name Time Method New ischemic stroke any time within 90 days Incidence of any new ischemic stroke
New vascular events any time within 90 days Incidence of any new vascular events, including ischemic stroke, hemorrhagic stroke, TIA, myocardial infarction and vascular death
Poor functional outcome at 90 days after randomization Rate of poor functional outcome defined as a Modified Rankin Scale score of \>1 (Modified Rankin Scale score ranges from 0 (no symptoms) to 6 (death) and higher score means worse outcome)
New stroke and TIA any time within 90 days Incidence of any new stroke and TIA
Severity of recurrent stroke and TIA within 90 days after randomization Severity is measured using a six-level ordered categorical scale that incorporates the mRS: fatal stroke \[mRS 6\]/severe non-fatal stroke \[mRS 4 or 5\]/moderate stroke \[mRS 2 or 3\]/mild stroke \[mRS 0 or 1\]/TIA/no stroke-TIA
Trial Locations
- Locations (244)
Baoding Xushui District People's Hospital
🇨🇳Baoding, Hebei, China
Hebei Tang County People Hospital
🇨🇳Baoding, Hebei, China
People's Hospital of Zhongwei
🇨🇳Zhongwei, Ningxia, China
Xichuan County People's Hospital
🇨🇳Nanyang, Henan, China
Ruzhou People's Hospital
🇨🇳Pingdingshan, Henan, China
Puyang County People's Hospital
🇨🇳Puyang, Henan, China
Shaodong People's Hospital
🇨🇳Shaoyang, Hunan, China
Qingfeng xinxing hospital
🇨🇳Puyang, Henan, China
Sui county traditional Chinese medicine hospital
🇨🇳Shangqiu, Henan, China
Baotou City Central Hospital
🇨🇳Baotou, Inner Mongolia, China
Suxitong Science and Technology Industrial Park People's Hospital
🇨🇳Nantong, Jiangsu, China
Yichun People's Hospital
🇨🇳Yichun, Jiangxi, China
Siping Central People's Hospital
🇨🇳Siping, Jilin, China
Central Hospital of Zhuanghe City
🇨🇳Dalian, Liaoning, China
Linyi Central Hospital
🇨🇳Linyi, Shandong, China
Yantai Penglai People's Hospital
🇨🇳Yantai, Shandong, China
Yunnan Nujiang Lisu Autonomous Prefecture People's Hospital
🇨🇳Nujiang, Yunnan, China
Zibo Municipal Hospital
🇨🇳Zibo, Shandong, China
Jiyuan Hospital of Traditional Chinese Medicine
🇨🇳Jiyuan, Henan, China
Qinyang People's Hospital
🇨🇳Jiaozuo, Henan, China
Wuzhi County People's Hospital
🇨🇳Jiaozuo, Henan, China
Kaifeng Central Hospital
🇨🇳Kaifeng, Henan, China
The First Affiliated Hospital of Wannan Medical College
🇨🇳Wuhu, Anhui, China
Huangshan City People's Hospital
🇨🇳Huangshan, Anhui, China
Linquan County People's Hospital
🇨🇳Fuyang, Anhui, China
Beijing Tiantan Hospital, Capital Medical University
🇨🇳Beijing, Beijing, China
The First People's Hospital of Wuhu
🇨🇳Wuhu, Anhui, China
Beijing Shunyi Airport Hospital
🇨🇳Beijing, Beijing, China
Beijing Shunyi Hospital
🇨🇳Beijing, Beijing, China
Fuxing Hospital, Capital Medical University
🇨🇳Beijing, Beijing, China
Xiuwu County People's Hospital
🇨🇳Jiaozuo, Henan, China
The First Hospital of Fangshan District, Beijing
🇨🇳Beijing, Beijing, China
Chongqing Sanbo Chang 'an Hospital
🇨🇳Chongqing, Chongqing, China
Chongqing Tungwah Hospital
🇨🇳Chongqing, Chongqing, China
Chongqing University Fuling Hospital
🇨🇳Chongqing, Chongqing, China
The Second Affiliated Hospital of Chongqing Medical University
🇨🇳Chongqing, Chongqing, China
The First Affiliated Hospital of Chongqing Medical and Pharmaceutical College
🇨🇳Chongqing, Chongqing, China
Ningde People's Hospital
🇨🇳Ningde, Fujian, China
Xiushan Tujia and Miao Autonomous County People's Hospital
🇨🇳Chongqing, Chongqing, China
The Sanming First Hospital Affiliated to Fujian Medical University
🇨🇳Sanming, Fujian, China
The First Affiliated Hospital of Xiamen University
🇨🇳Xiamen, Fujian, China
The Second affiliated Hospital of Xiamen Medical College
🇨🇳Xiamen, Fujian, China
The Third Hospital of Xiamen
🇨🇳Xiamen, Fujian, China
The First People's Hospital of Lanzhou City
🇨🇳Lanzhou, Gansu, China
Zhangye People's Hospital Affiliated To Hexi University
🇨🇳Zhangye, Gansu, China
The First People's Hospital of Foshan
🇨🇳Foshan, Guangdong, China
Guangdong second Provincial Central Hospital
🇨🇳Guangzhou, Guangdong, China
The Fifth Affiliated Hospital of Jinan University (Heyuan Shenhe People's Hospital)
🇨🇳Heyuan, Guangdong, China
The First Affiliated Hospital of Jinan University
🇨🇳Guangzhou, Guangdong, China
Huizhou First Hospital
🇨🇳Huizhou, Guangdong, China
Guihang Guiyang hospital
🇨🇳Guizhou, Guiyang, China
Puding County People's Hospital
🇨🇳Anshun, Guizhou, China
The People's Hospital of Cenxi City
🇨🇳Wuzhou, Guangxi, China
Zhejiang Provincial People's Hospital Bijie Hospital
🇨🇳Bijie, Guizhou, China
The Second People's Hospital of Guiyang
🇨🇳Guiyang, Guizhou, China
The First People's Hospital of Guiyang
🇨🇳Guiyang, Guizhou, China
The Third People's Hospital of Guiyang
🇨🇳Guiyang, Guizhou, China
The People's Hospital of the Qiandongnan Miao and Dong Autonomous Prefecture
🇨🇳Kaili, Guizhou, China
The second Affiliated Hospital of Guizhou Medical University
🇨🇳Kaili, Guizhou, China
Qianxinan Buyi and Miao Autonomous Prefecture People's Hospital
🇨🇳Xingyi, Guizhou, China
The Second Affiliated Hospital of Hainan Medical University
🇨🇳Haikou, Hainan, China
Affiliated Hospital of Hebei University
🇨🇳Baoding, Hebei, China
The Hospital of Anguo City
🇨🇳Baoding, Hebei, China
Chengde County Hospital
🇨🇳Chengde, Hebei, China
Shunping County Hospital
🇨🇳Baoding, Hebei, China
Wangdu County Hospital,Hebei Province
🇨🇳Baoding, Hebei, China
Handan First Hospital
🇨🇳Handan, Hebei, China
Guantao county central Hospital
🇨🇳Handan, Hebei, China
Affiliated Hospital of Chengde Medical University
🇨🇳Chengde, Hebei, China
Qiu County Hospital of Traditional Chinese Medicine
🇨🇳Handan, Hebei, China
Hejian People's Hospital
🇨🇳Hejian, Hebei, China
Qiu County People's Hospital
🇨🇳Handan, Hebei, China
Hengshui People's Hospital
🇨🇳Hengshui, Hebei, China
The No.4 People's Hospital of Hengshui(Department of Neurology ward 1)
🇨🇳Hengshui, Hebei, China
The No.4 People's Hospital of Hengshui(Department of Neurology ward 2)
🇨🇳Hengshui, Hebei, China
Shijiazhuang Third Hospital
🇨🇳Shijiazhuang, Hebei, China
The Second Hospital of Hebei Medical University
🇨🇳Shijiazhuang, Hebei, China
North China University of Science And Technology Affiliated Hospital
🇨🇳Tangshan, Hebei, China
Qinghe people's hospital
🇨🇳Xingtai, Hebei, China
Tangshan Gongren Hospital
🇨🇳Tangshan, Hebei, China
The First Affiliated Hospital of Hebei North University
🇨🇳Zhangjiakou, Hebei, China
Werixian People's Hospital
🇨🇳Xingtai, Hebei, China
The 2nd Affiliated Hospital of Harbin Medical University
🇨🇳Harbin, Heilongjiang, China
The First Affiliated Hospital of Harbin Medical University
🇨🇳Harbin, Heilongjiang, China
Hongxinglong Hospital of Beidahuang Group
🇨🇳Shuangyashan, Heilongjiang, China
The People's Hospital of Anyang City
🇨🇳Anyang, Henan, China
Dengzhou Central Hospital
🇨🇳Dezhou, Henan, China
Hebi Coal Industry (Group) Co., Ltd. General Hospital
🇨🇳Hebi, Henan, China
Boai People's Hospital
🇨🇳Jiaozuo, Henan, China
Mengzhou Hospital of Traditional Chinese Medicine
🇨🇳Jiaozuo, Henan, China
Mengzhou People's Hospital(Department of Neurology ward 1)
🇨🇳Jiaozuo, Henan, China
Mengzhou People's Hospital(Department of Neurology ward 2)
🇨🇳Jiaozuo, Henan, China
Qinyang City Hospital of Traditional Chinese Medicine
🇨🇳Jiaozuo, Henan, China
Lankao County Central Hospital
🇨🇳Kaifeng, Henan, China
Weishi Central Hospital
🇨🇳Kaifeng, Henan, China
Luoning County People's Hospital
🇨🇳Luoyang, Henan, China
Luoyang Central Hospital
🇨🇳Luoyang, Henan, China
Luoyang First People's Hospital
🇨🇳Luoyang, Henan, China
Luoyang Dongfang People's Hospital
🇨🇳Luoyang, Henan, China
Luoyang Mengjin District People's Hospital
🇨🇳Luoyang, Henan, China
Ruyang People's Hospital
🇨🇳Luoyang, Henan, China
Neixiang County People's Hospital
🇨🇳Nanyang, Henan, China
The Second Affiliated Hospital of Henan University of Science and Technology
🇨🇳Luoyang, Henan, China
Yiyang County People's Hospital
🇨🇳Luoyang, Henan, China
Nanyang Second General Hospital
🇨🇳Nanyang, Henan, China
Xixia County People's Hospital
🇨🇳Nanyang, Henan, China
The second people's hospital of Pingdingshan
🇨🇳Pingdingshan, Henan, China
Ye County People's Hospital
🇨🇳Pingdingshan, Henan, China
Fanxian People's Hospital
🇨🇳Puyang, Henan, China
The First People Hospital of Lingbao
🇨🇳Sanmenxia, Henan, China
The Fourth People's Hospital of Shangqiu
🇨🇳Shangqiu, Henan, China
The Shangqiu First People's Hospital
🇨🇳Shangqiu, Henan, China
Zhecheng People's Hospital
🇨🇳Shangqiu, Henan, China
Huixian People's Hospital
🇨🇳Xinxiang, Henan, China
The second People Hospital of Xinxiang Henan
🇨🇳Xinxiang, Henan, China
The Affiliated Hospital of Xinyang Vocational and Technical College
🇨🇳Xinyang, Henan, China
Xingyang People's Hospital
🇨🇳Zhengzhou, Henan, China
Xinxiang tongmeng hospital
🇨🇳Xinxiang, Henan, China
Central Hospital of Yongcheng
🇨🇳Yongcheng, Henan, China
Taikang Xian People's Hospital
🇨🇳Zhoukou, Henan, China
Xinmi Hospital of T.C.M
🇨🇳Zhengzhou, Henan, China
Shenqiu County People's Hospital
🇨🇳Zhoukou, Henan, China
Xihua Xian People's Hospital
🇨🇳Zhoukou, Henan, China
Chenzhou No.1 People's Hospital
🇨🇳Chenzhou, Hunan, China
Zhumadian TCM Hospital
🇨🇳Zhumadian, Henan, China
The Third People's Hospital of Chenzhou
🇨🇳Chenzhou, Hunan, China
The Fourth People's Hospital of Chenzhou
🇨🇳Chenzhou, Hunan, China
Yueyang People's Hospital
🇨🇳Yueyang, Hunan, China
Hengyang Central Hospital
🇨🇳Hengyang, Hunan, China
Sinopharm North Hospital
🇨🇳Baotou, Inner Mongolia, China
The First Affiliated Hospital of Baotou Medical College
🇨🇳Baotou, Inner Mongolia, China
Wuyuan County People's Hospital
🇨🇳Bayan Nur, Inner Mongolia, China
The people's Hospital of Wulateqianqi
🇨🇳Bayan Nur, Inner Mongolia, China
Huhhot First Hospital
🇨🇳Hohhot, Inner Mongolia, China
Inner Mongolia International Mongolian Hospital
🇨🇳Hohhot, Inner Mongolia, China
Inner Mongolia Forestry General Hospital
🇨🇳Hulunbuir, Inner Mongolia, China
Ordos central hospital
🇨🇳Ordos, Inner Mongolia, China
Inner Mongolia People's Hospital
🇨🇳Hohhot, Inner Mongolia, China
The people's Hospital of Wuhai
🇨🇳Wuhai, Inner Mongolia, China
Nanjing Gaochun People's Hospital
🇨🇳Nanjing, Jiangsu, China
Affiliated Hospital of Inner Mongolia Minzu University
🇨🇳Tongliao, Inner Mongolia, China
Ulanpab Central Hospital
🇨🇳Ulanqab, Inner Mongolia, China
Tongliao City Hospital
🇨🇳Tongliao, Inner Mongolia, China
Tuoketuo County Hospital
🇨🇳Hohhot, Inner Mongoria, China
Jiangsu Rudong County People's Hospital
🇨🇳Nantong, Jiangsu, China
Nantong Tongzhou District No.8 People's Hospital
🇨🇳Nantong, Jiangsu, China
The People's Hospital of Rugao
🇨🇳Nantong, Jiangsu, China
Nanjing Drum Tower Hospital Group Suqian Hospital
🇨🇳Suqian, Jiangsu, China
The Sixth People's Hospital of Nantong
🇨🇳Nantong, Jiangsu, China
Siyang kangda hospital
🇨🇳Suqian, Jiangsu, China
Xinghua City People's Hospital
🇨🇳Taizhou, Jiangsu, China
Jiangyin People's Hospital
🇨🇳Wuxi, Jiangsu, China
Yixing People's Hospital
🇨🇳Wuxi, Jiangsu, China
The Second Affiliated Hospital of Xuzhou Medical University
🇨🇳Xuzhou, Jiangsu, China
Nanfang Hospital，Ganzhou
🇨🇳Ganzhou, Jiangxi, China
Jingdezhen No.1 People's Hospital
🇨🇳Jingdezhen, Jiangxi, China
Jiujiang No.1 People's Hospital
🇨🇳Jiujiang, Jiangxi, China
Fuzhou First People's Hospital of Jiangxi Province
🇨🇳Fuzhou, Jiangxi, China
Jiujiang University Affiliated Hospital
🇨🇳Jiujiang, Jiangxi, China
ShangRao People's Hospital
🇨🇳Shangrao, Jiangxi, China
Jiangxi Provincial People's Hospital
🇨🇳Nanchang, Jiangxi, China
Yugan Xinjiang hospital
🇨🇳Shangrao, Jiangxi, China
Tonggu County People's Hospital
🇨🇳Yichun, Jiangxi, China
Meihekou Central Hospital
🇨🇳Meihekou, Jilin, China
China-Japan Union Hospital of Jilin University
🇨🇳Changchun, Jilin, China
Anshan Central Hospital
🇨🇳Anshan, Liaoning, China
Affiliated Zhongshan Hospital of Dalian University
🇨🇳Dalian, Liaoning, China
Central Hospital of Wafangdian
🇨🇳Dalian, Liaoning, China
Dalian Lvshun District People's Hospital
🇨🇳Dalian, Liaoning, China
Dalian Jinzhou District First People's Hospital
🇨🇳Dalian, Liaoning, China
Dalian Lvshun District Hospitai of tradition Chinese Medicine
🇨🇳Dalian, Liaoning, China
Dalian Municipal Central Hospital
🇨🇳Dalian, Liaoning, China
Dalian PuLanDian central hospital
🇨🇳Dalian, Liaoning, China
Dalian University Affiliated Xinhua Hospital
🇨🇳Dalian, Liaoning, China
Shengjing Hospital of China Medical University
🇨🇳Shenyang, Liaoning, China
The Second People's Hospital of Huludao
🇨🇳Huludao, Liaoning, China
Panjin Central Hospital
🇨🇳Panjin, Liaoning, China
Affiliated Hospital of Liaoning University of Traditional Chinese Medicine
🇨🇳Shenyang, Liaoning, China
The People's Hospital of Liaoning Province
🇨🇳Shenyang, Liaoning, China
Ankang Central Hospital
🇨🇳Ankang, Shaanxi, China
Xianyang Hospital of Yan 'an University
🇨🇳Xianyang, Shaanxi, China
Xi 'an Fengcheng Hospital
🇨🇳Xi'an, Shaanxi, China
East District of The First Affiliated Hospital of Xi'an Jiaotong University
🇨🇳Xi'an, Shaanxi, China
Weihai Wendeng District People's Hospital
🇨🇳Weihai, Shandogn, China
Zichang People's Hospital
🇨🇳Yanan, Shaanxi, China
Yangxin County People Hospital
🇨🇳Binzhou, Shandong, China
Binzhou Central Hospital
🇨🇳Binzhou, Shandong, China
The Second People's Hospital of Dongying
🇨🇳Dongying, Shandong, China
Ningjin People's Hospital
🇨🇳Dezhou, Shandong, China
People's Hospital of Qihe County
🇨🇳Dezhou, Shandong, China
Yuncheng County People's Hospital
🇨🇳Heze, Shandong, China
Guanxian People's Hospital
🇨🇳Liaocheng, Shandong, China
Affiliated Hospital of Shandong University of Traditional Chinese Medicine
🇨🇳Jinan, Shandong, China
Liaocheng City Central Hospital
🇨🇳Liaocheng, Shandong, China
Liaocheng People's Hospital（Liaocheng Brain Hospital）
🇨🇳Liaocheng, Shandong, China
Liaocheng People's Hospital
🇨🇳Liaocheng, Shandong, China
The people's Hospital of Linqing
🇨🇳Liaocheng, Shandong, China
The People's Hospital of Gaotang
🇨🇳Liaocheng, Shandong, China
Third People's Hospital of Liaocheng
🇨🇳Liaocheng, Shandong, China
The Second People's Hospital of Liaocheng
🇨🇳Liaocheng, Shandong, China
Yanggu Traditional Chinese Medical Hospital
🇨🇳Liaocheng, Shandong, China
Linyi People's Hospital
🇨🇳Linyi, Shandong, China
Linyi Third People's Hospital
🇨🇳Linyi, Shandong, China
Linyi Traditional Chinese Medicine Hospital
🇨🇳Linyi, Shandong, China
Qingdao Fuwai Cardiovascular Hospital
🇨🇳Qingdao, Shandong, China
People's Hospital of Yinan
🇨🇳Linyi, Shandong, China
Qixia City People's Hospital
🇨🇳Qixian, Shandong, China
Weihai Central Hospital
🇨🇳Weihai, Shandong, China
Weihai Municipal Hospital
🇨🇳Weihai, Shandong, China
Qixia traditional Chinese medicine hospital
🇨🇳Yantai, Shandong, China
Yantai Affiliated Hospital of Binzhou Medical University
🇨🇳Yantai, Shandong, China
Yantai Taocun Central Hospital
🇨🇳Yantai, Shandong, China
Yantai Penglai traditional Chinese medicine hospital
🇨🇳Yantai, Shandong, China
Yicheng Municipal Hospital of Zaozhuang
🇨🇳Zaozhuang, Shandong, China
Yantai Yuhuangding Hospital
🇨🇳Yantai, Shandong, China
Yantai Zhifu hospital
🇨🇳Yantai, Shandong, China
YEDA hospital
🇨🇳Yantai, Shandong, China
Zibo Central Hospital
🇨🇳Zibo, Shandong, China
PKUcare Zibo Hospital
🇨🇳Zibo, Shandong, China
Zibo Hospital of Traditional Chinese Medicine
🇨🇳Zibo, Shandong, China
Shanghai Seventh People's Hospital
🇨🇳Shanghai, Shanghai, China
Linfen Central Hospital(emergency department)
🇨🇳Linfen, Shanxi, China
Second Hospital of Shanxi Medical University
🇨🇳Taiyuan, Shanxi, China
Yueyang Hospital of Integrated Traditional Chinese and Western Medicine,Shanghai University of Traditional Chinese Medicine
🇨🇳Shanghai, Shanghai, China
Linfen Central Hospital (neurology department)
🇨🇳Linfen, Shanxi, China
Shanxi Bethune Hospital
🇨🇳Taiyuan, Shanxi, China
Shanxi Cardiovascular Hospital
🇨🇳Taiyuan, Shanxi, China
The First People's Hospital of Longquanyi Disdrict,Chengdu
🇨🇳Chengdu, Sichuan, China
Sichuan Provincial People's Hospital
🇨🇳Chengdu, Sichuan, China
People's Hospital of Deyang City
🇨🇳Deyang, Sichuan, China
The Third Hospital of Mianyang
🇨🇳Mianyang, Sichuan, China
The Second People's Hospital of Neijiang
🇨🇳Neijiang, Sichuan, China
Panzhihua Central Hospital
🇨🇳Panzhihua, Sichuan, China
The First Affiliated Hospital of Shihezi University
🇨🇳Shihezi, Xinjiang, China
People's Hospital of Xinjiang Uygur Autonomous Region, Urumqi, China
🇨🇳Urumqi, Xinjiang, China
First Affiliated Hospital of Kunming Medical University
🇨🇳Kunming, Yunnan, China
Ninger County People's Hospital
🇨🇳Pu'er, Yunnan, China
Tengchong People's Hospital
🇨🇳Tengchong, Yunnan, China
The First People's Hospital of jiande
🇨🇳Hangzhou, Zhejiang, China
People's Hospital of Anji
🇨🇳Huzhou, Zhejiang, China
Juancheng County People's Hospital
🇨🇳Heze, China
Haiyan People's Hospital
🇨🇳Jiaxing, Zhejiang, China
Baise City People's Hospital
🇨🇳Baise, Guangxi, China
Guyuan people's hospital
🇨🇳Guyuan, Ningxia, China