Colchicine effects on treatment of COVID-19

Phase 2

Recruiting

Conditions: COVID-19 pneumonia.
COVID-19, virus identified
U07.1

Registration Number: IRCT20190804044429N5

Lead Sponsor: Mazandaran University of Medical Sciences

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Recruiting

Sex: All

Target Recruitment: 110

Inclusion Criteria

Inclusion criteria are adults over the age of 18 with a diagnosis of COVID-19 based on clinical criteria (presence of any symptoms of cough, shortness of breath, fever, and CT scan of the lung for evidence of involvement consistent with COVID-19 infection) or PCR and
Had clinical symptoms of COVID-19 within two weeks

Exclusion Criteria

Pregnancy and lactation
Severe hepatic insufficiency (Child-pugh C)
Renal insufficiency (GFR less than 30 ml/min)
Allergy history of colchicine
Thrombocytopenia (Platelets less than 100,000 /mm3)
Not consent

Study & Design

Study Type: interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Respiratory rate. Timepoint: Before intervention and daily during the study. Method of measurement: physical exam.;Blood oxygen saturation. Timepoint: Before intervention and daily during the study. Method of measurement: pulse oximeter.;Fever recovery. Timepoint: Before intervention and daily during the study. Method of measurement: thermometer.;Therapeutic regimen safety. Timepoint: Daily during the study. Method of measurement: Incidence of any side effects.;CRP. Timepoint: before intervention and then three times weekly during the study. Method of measurement: CRP laboratory kite.;Lymphocyte count. Timepoint: before intervention and then daily during the study. Method of measurement: Cell blood count test.

Secondary Outcome Measures

Name	Time	Method
Hospital stay duration. Timepoint: End of treatment. Method of measurement: Patient file.;Mortality rate. Timepoint: Daily during the study. Method of measurement: patient file.